Fujimoto K, Sakata T, Arase K, Kurata K, Okabe Y, Shiraishi T
Life Sci. 1985 Dec 30;37(26):2475-82. doi: 10.1016/0024-3205(85)90604-6.
D-glucosamine, 2-amino-2-deoxy-D-glucose, is known to be an endogenous glucose analogue and to antagonize glucose uptake and metabolism. The present experiments were aimed to clarify effects of glucosamine and related chemical substances on ingestive behavior, as well as its direct effects on hypothalamic neurons. Infusion of 24 mumole glucosamine into the third cerebroventricle induced feeding within 30 min in 5 rats out of 7 tested, accompanied by increased ambulatory activity. No periprandial drinking was observed. Plasma glucose level increased, peaking at 30 min after the injection. Plasma insulin level tended to increase, but not significantly. Electrophoretic application of glucosamine activated glucose-sensitive neurons in the lateral hypothalamus and suppressed glucoreceptors in the ventromedial hypothalamus. These facts, together with other reported results, suggest that glucosamine can modulate physiological feeding and that carbon 2 of the glucose molecule is important in feeding modulation by glucose analogues.
D - 葡萄糖胺，即2 - 氨基 - 2 - 脱氧 - D - 葡萄糖，已知是一种内源性葡萄糖类似物，可拮抗葡萄糖摄取和代谢。本实验旨在阐明葡萄糖胺及相关化学物质对摄食行为的影响，以及它们对下丘脑神经元的直接作用。向第三脑室注入24微摩尔葡萄糖胺后，在7只受试大鼠中有5只在30分钟内引发进食，同时伴有活动量增加。未观察到餐时饮水现象。血浆葡萄糖水平升高，在注射后30分钟达到峰值。血浆胰岛素水平有升高趋势，但不显著。电泳施加葡萄糖胺可激活下丘脑外侧的葡萄糖敏感神经元，并抑制腹内侧下丘脑的葡萄糖感受器。这些事实，连同其他已报道的结果，表明葡萄糖胺可调节生理性摄食，且葡萄糖分子的2号碳在葡萄糖类似物对摄食的调节中很重要。
