de Faria Eduardo B, Barrow Kory R, Ruehle Bradley T, Parker Jordan T, Swartz Elisa, Taylor-Howell Cheryl, Kieta Kaitlyn M, Lees Cynthia J, Sleeper Meg M, Dobbin Travis, Baron Adam D, Mohindra Pranshu, MacVittie Thomas J
*University of Maryland, School of Medicine, Department of Radiation Oncology, Preclinical Radiobiology Laboratory, Echocardiography and Computed Tomography Team; †University of Maryland, School of Medicine, Department of Radiation Oncology, Preclinical Radiobiology Laboratory, Computed Tomography Team; ‡University of Maryland, School of Medicine, Department of Radiation Oncology, Preclinical Radiobiology Laboratory, Echocardiography Team; §Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, NC; **Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Gainesville, FL; ††University of Maryland, School of Medicine, Department of Radiation Oncology, Baltimore, MD.
Health Phys. 2015 Nov;109(5):479-92. doi: 10.1097/HP.0000000000000344.
Computed Tomography (CT) and Echocardiography (EC) are two imaging modalities that produce critical longitudinal data that can be analyzed for radiation-induced organ-specific injury to the lung and heart. The Medical Countermeasures Against Radiological Threats (MCART) consortium has a well established animal model research platform that includes nonhuman primate (NHP) models of the acute radiation syndrome and the delayed effects of acute radiation exposure. These models call for a definition of the latency, incidence, severity, duration, and resolution of different organ-specific radiation-induced subsyndromes. The pulmonary subsyndromes and cardiac effects are a pair of interdependent syndromes impacted by exposure to potentially lethal doses of radiation. Establishing a connection between these will reveal important information about their interaction and progression of injury and recovery. Herein, the authors demonstrate the use of CT and EC data in the rhesus macaque models to define delayed organ injury, thereby establishing: a) consistent and reliable methodology to assess radiation-induced damage to the lung and heart; b) an extensive database in normal age-matched NHP for key primary and secondary endpoints; c) identified problematic variables in imaging techniques and proposed solutions to maintain data integrity; and d) initiated longitudinal analysis of potentially lethal radiation-induced damage to the lung and heart.
计算机断层扫描（CT）和超声心动图（EC）是两种成像方式，它们能产生关键的纵向数据，可用于分析辐射引起的肺部和心脏特定器官损伤。应对放射威胁医学对策（MCART）联盟拥有一个成熟的动物模型研究平台，其中包括急性放射综合征的非人灵长类动物（NHP）模型以及急性辐射暴露的延迟效应模型。这些模型需要对不同器官特异性辐射诱发亚综合征的潜伏期、发病率、严重程度、持续时间和恢复情况进行定义。肺部亚综合征和心脏效应是一对相互依存的综合征，受到潜在致死剂量辐射暴露的影响。建立它们之间的联系将揭示有关其相互作用以及损伤和恢复进展的重要信息。在此，作者展示了在恒河猴模型中使用CT和EC数据来定义延迟性器官损伤，从而建立了：a）评估辐射对肺和心脏损伤的一致且可靠的方法；b）针对正常年龄匹配的NHP的关键主要和次要终点建立了广泛的数据库；c）识别了成像技术中的问题变量并提出了维护数据完整性的解决方案；d）启动了对潜在致死性辐射引起的肺和心脏损伤的纵向分析。
