一种用于表征辐射诱导的肺损伤及医学对策研发的基质辅助激光解吸电离质谱成像方法。
A MALDI-MSI Approach to the Characterization of Radiation-Induced Lung Injury and Medical Countermeasure Development.
作者信息
Carter Claire L, Jones Jace W, Barrow Kory, Kieta Kaitlyn, Taylor-Howell Cheryl, Kearney Sean, Smith Cassandra P, Gibbs Allison, Farese Ann M, MacVittie Thomas J, Kane Maureen A
机构信息
*University of Maryland, School of Pharmacy, Department of Pharmaceutical Sciences, Baltimore, MD 21201; †University of Maryland, School of Medicine, Department of Radiation Oncology, Baltimore, MD 21201.
出版信息
Health Phys. 2015 Nov;109(5):466-78. doi: 10.1097/HP.0000000000000353.
Abstract
Radiation-induced lung injury is highly complex and characterized by multiple pathologies, which occur over time and sporadically throughout the lung. This complexity makes biomarker investigations and medical countermeasure screenings challenging. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has the ability to resolve differences spatially in molecular profiles within the lung following radiation exposure and can aid in biomarker identification and pharmaceutical efficacy investigations. MALDI-MSI was applied to the investigation of a whole-thorax lung irradiation model in non-human primates (NHP) for lipidomic analysis and medical countermeasure distribution.
摘要
辐射诱导的肺损伤非常复杂，具有多种病理特征，这些病理特征会随着时间的推移在肺部散在出现。这种复杂性使得生物标志物研究和医学对策筛选具有挑战性。基质辅助激光解吸/电离质谱成像（MALDI-MSI）能够在辐射暴露后在肺部空间分辨分子谱的差异，并有助于生物标志物鉴定和药物疗效研究。MALDI-MSI被应用于非人类灵长类动物（NHP）全胸肺部照射模型的研究，用于脂质组学分析和医学对策分布研究。
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