对一种同位素标记的有机金属钌（II）药物进行纳米二次离子质谱分析，以探究其在体外的分布和状态。
NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro.
作者信息
Lee Ronald F S, Escrig Stéphane, Croisier Marie, Clerc-Rosset Stéphanie, Knott Graham W, Meibom Anders, Davey Curt A, Johnsson Kai, Dyson Paul J
机构信息
Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
Laboratory for Biological Geochemistry, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
出版信息
Chem Commun (Camb). 2015 Nov 28;51(92):16486-9. doi: 10.1039/c5cc06983a.
The in vitro inter- and intra-cellular distribution of an isotopically labelled ruthenium(II)-arene (RAPTA) anti-metastatic compound in human ovarian cancer cells was imaged using nano-scale secondary ion mass spectrometry (NanoSIMS). Ultra-high resolution isotopic images of (13)C, (15)N, and Ru indicate that the phosphine ligand remains coordinated to the ruthenium(II) ion whereas the arene detaches. The complex localizes mainly on the membrane or at the interface between cells which correlates with its anti-metastatic effects.
利用纳米二次离子质谱（NanoSIMS）对一种同位素标记的钌（II）-芳烃（RAPTA）抗转移化合物在人卵巢癌细胞中的细胞间和细胞内体外分布进行成像。（13）C、（15）N和Ru的超高分辨率同位素图像表明，膦配体仍与钌（II）离子配位，而芳烃则脱离。该复合物主要定位于细胞膜或细胞间界面，这与其抗转移作用相关。
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