Piette W W, Stone M S
Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City 52242.
Arch Dermatol. 1989 Jan;125(1):53-6.
A series of patients shared the distinctive cutaneous findings of palpable purpuric plaques with multifocal areas of hemorrhage or superficial necrosis within individual lesions and a retiform pattern of hemorrhage, superficial necrosis, or lesional margins. This pattern was looked for in every patient presenting with palpable purpura, but it was seen exclusively in the seven patients described herein. Each patient was found to have an IgA-associated small dermal vessel vasculitis that was proved to be leukocytoclastic in six of the seven patients. These distinctive cutaneous findings may be evidence of the presence of IgA deposition in patients with small-vessel leukocytoclastic vasculitis and may infer a different pathogenesis for lesion formation in some patients with IgA-associated vasculitis.
一系列患者具有独特的皮肤表现，即可触及的紫癜性斑块，单个皮损内有多处出血或浅表坏死区域，以及出血、浅表坏死或皮损边缘的网状形态。在每例出现可触及紫癜的患者中均寻找这种形态，但仅在本文所述的7例患者中见到。发现每名患者均患有IgA相关的小真皮血管血管炎，在7例患者中的6例中证实为白细胞破碎性血管炎。这些独特的皮肤表现可能是小血管白细胞破碎性血管炎患者中IgA沉积的证据，并且可能提示某些IgA相关血管炎患者皮损形成的发病机制不同。
