Taimr Pavel, Jongerius Vivian L, Pek Chulja J, Krak Nanda C, Hansen Bettina E, Janssen Harry L A, Metselaar Herold J, van Eijck Casper H J
Department of Hepatology and Gastroenterology, Erasmus Medical Center, Rotterdam, The Netherlands.
Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands.
Ultrasound Med Biol. 2015 Dec;41(12):3063-9. doi: 10.1016/j.ultrasmedbio.2015.06.019. Epub 2015 Oct 1.
The aim of this study is to provide a diagnostic performance evaluation of contrast-enhanced ultrasonography (CEUS) in detecting liver metastases in patients with suspected of pancreatic or periampullary cancer. Computed tomography (CT) is often insufficient for detection of liver metastases, but their presence plays a crucial role in the choice of therapy. Eighty-nine patients with suspected pancreatic or periampullary cancer were included in this prospective study with retrospective analysis. Patients underwent an abdominal CT and CEUS. Fifteen patients had liver metastases. The CT sensitivity was 73.3% (11/15), the specificity 93.2% (69/74), the positive predictive value (PPV) 68.8% (11/16) and the negative predictive value (NPV) 94.6% (69/73). Based on CEUS, the sensitivity was 80% (12/15), specificity 98.6% (73/74), PPV 92.3% (12/13) and NPV 96.1% (73/76). CEUS improved characterization of liver lesions in patients with suspected pancreatic or periampullary cancer compared with CT. CEUS can better detect benign liver lesions and distinguish false-positive or indeterminate CT results.
本研究的目的是对超声造影（CEUS）在检测疑似胰腺癌或壶腹周围癌患者肝转移灶方面的诊断性能进行评估。计算机断层扫描（CT）通常不足以检测肝转移灶，但其存在对治疗方案的选择起着关键作用。本前瞻性研究纳入了89例疑似胰腺癌或壶腹周围癌的患者，并进行回顾性分析。患者接受了腹部CT和CEUS检查。15例患者存在肝转移。CT的敏感性为73.3%（11/15），特异性为93.2%（69/74），阳性预测值（PPV）为68.8%（11/16），阴性预测值（NPV）为94.6%（69/73）。基于CEUS，敏感性为80%（12/15），特异性为98.6%（73/74），PPV为92.3%（12/13），NPV为96.1%（73/76）。与CT相比，CEUS改善了疑似胰腺癌或壶腹周围癌患者肝病灶的特征描述。CEUS能更好地检测肝脏良性病变，并区分CT的假阳性或不确定结果。
