Carvalho Livia S, Vandenberghe Luk H
Department of Ophthalmology, Ocular Genomics Institute, Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Harvard University, 20 Staniford Street, 02114, Boston, MA, USA.
Adv Exp Med Biol. 2016;854:231-6. doi: 10.1007/978-3-319-17121-0_31.
Colour vision is only achieved in the presence of healthy and functional cone photoreceptors found in the retina. It is an essential component of human vision and usually the first complaint patients undergoing vision degeneration have is the loss of daylight colour vision. Therefore, an understanding of the biology and basic mechanisms behind cone death under the degenerative state of retinal dystrophies and how the activation of the apoptotic pathway is triggered will provide valuable knowledge. It will also have broader applications for a spectrum of visual disorders and will be critical for future advances in translational research.
色觉只有在视网膜中存在健康且功能正常的视锥光感受器时才能实现。它是人类视觉的重要组成部分，通常视力退化患者首先抱怨的就是日光色觉丧失。因此，了解视网膜营养不良退化状态下视锥细胞死亡背后的生物学和基本机制，以及凋亡途径的激活是如何触发的，将提供有价值的知识。它还将在一系列视觉障碍中具有更广泛的应用，并且对于转化研究的未来进展至关重要。
