Lahne Manuela, Hyde David R
Department of Biological Sciences and the Center for Zebrafish Research, University of Notre Dame, Galvin Life Sciences Building, 46556, Notre Dame, IN, USA.
Department of Biological Sciences and the Center for Zebrafish Research, University of Notre Dame, 027 Galvin Life Sciences Building, 46556, Notre Dame, IN, USA.
Adv Exp Med Biol. 2016;854:587-93. doi: 10.1007/978-3-319-17121-0_78.
In the adult zebrafish, death of retinal neurons stimulates Müller glia to re-enter the cell cycle to produce neuronal progenitor cells (NPCs) that undergo further cell divisions and differentiate to replace lost neurons in the correct spatial locations. Understanding the mechanisms regulating retinal regeneration will ultimately provide avenues to overcome vision loss in human. Recently, the observation of interkinetic nuclear migration (INM) of Müller glia in the regenerating zebrafish retina resulted in the inclusion of an additional complex step to the regeneration process. The pathways regulating INM and its function in the regenerating retina have not been well studied. Here, we summarize the evidence for INM in the regenerating retina and review mechanisms that control INM during neuro-epithelial development in the context of pathways known to be critical during retinal regeneration.
在成年斑马鱼中，视网膜神经元的死亡会刺激米勒胶质细胞重新进入细胞周期，以产生神经元祖细胞（NPCs），这些祖细胞会进一步进行细胞分裂并分化，从而在正确的空间位置替代丢失的神经元。了解调节视网膜再生的机制最终将为克服人类视力丧失提供途径。最近，在再生斑马鱼视网膜中观察到米勒胶质细胞的核间运动（INM），这使得再生过程又增加了一个复杂步骤。调节INM及其在再生视网膜中功能的途径尚未得到充分研究。在这里，我们总结了再生视网膜中INM的证据，并在已知对视网膜再生至关重要的途径背景下，回顾了神经上皮发育过程中控制INM的机制。
