干细胞衍生血管系统：一种用于基础研究、疾病建模和组织工程的强大且多维度的技术。
Stem cell-derived vasculature: A potent and multidimensional technology for basic research, disease modeling, and tissue engineering.
作者信息
Lowenthal Justin, Gerecht Sharon
机构信息
Medical Scientist Training Program, School of Medicine, Johns Hopkins University, Baltimore, MD, United States; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States.
Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, United States; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, United States; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, United States.
出版信息
Biochem Biophys Res Commun. 2016 May 6;473(3):733-42. doi: 10.1016/j.bbrc.2015.09.127. Epub 2015 Sep 30.
Proper blood vessel networks are necessary for constructing and re-constructing tissues, promoting wound healing, and delivering metabolic necessities throughout the body. Conversely, an understanding of vascular dysfunction has provided insight into the pathogenesis and progression of diseases both common and rare. Recent advances in stem cell-based regenerative medicine - including advances in stem cell technologies and related progress in bioscaffold design and complex tissue engineering - have allowed rapid advances in the field of vascular biology, leading in turn to more advanced modeling of vascular pathophysiology and improved engineering of vascularized tissue constructs. In this review we examine recent advances in the field of stem cell-derived vasculature, providing an overview of stem cell technologies as a source for vascular cell types and then focusing on their use in three primary areas: studies of vascular development and angiogenesis, improved disease modeling, and the engineering of vascularized constructs for tissue-level modeling and cell-based therapies.
合适的血管网络对于构建和重建组织、促进伤口愈合以及在全身输送代谢所需物质是必要的。相反，对血管功能障碍的理解为洞察常见和罕见疾病的发病机制及进展提供了线索。基于干细胞的再生医学的最新进展——包括干细胞技术的进步以及生物支架设计和复杂组织工程的相关进展——使得血管生物学领域取得了快速进展，进而带来了更先进的血管病理生理学模型以及血管化组织构建体的改进工程。在本综述中，我们研究了干细胞衍生脉管系统领域的最新进展，概述了作为血管细胞类型来源的干细胞技术，然后重点关注其在三个主要领域的应用：血管发育和血管生成研究、改进的疾病建模，以及用于组织水平建模和基于细胞疗法的血管化构建体工程。
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