Skyler J S
Diabetes Educ. 1989 Jan-Feb;15(1):33-9. doi: 10.1177/014572178901500110.
Intensive therapy of Type I diabetes is a system of therapy in which the patient is the key partner in day-to-day management. A number of technical developments in the late 1970s led to the development of intensive therapy. Self-monitoring of blood glucose (SMBG) proved to be the major change agent that stimulated the revolution in diabetes management that is intensive therapy. One important event that stimulated widespread use of SMBG was the development of spring-loaded finger-pricking devices. The introduction of glycated hemoglobin measurements as an indicator of glycemic control over several weeks allowed quantitative assessment of glycemic control. The advent of continuous subcutaneous insulin infusion (CSII) stimulated thinking about insulin regimens. These advances have combined not only to facilitate development of intensive therapy as a strategy of diabetes management, but also to permit development of research protocols to assess the impact of such therapy on the chronic complications of diabetes.
1型糖尿病强化治疗是一种治疗体系，在该体系中患者是日常管理的关键伙伴。20世纪70年代末的一些技术发展促成了强化治疗的出现。血糖自我监测（SMBG）被证明是引发糖尿病管理革命即强化治疗的主要变革因素。推动SMBG广泛应用的一个重要事件是弹簧式手指采血装置的研发。糖化血红蛋白测量作为数周血糖控制指标的引入，使得能够对血糖控制进行定量评估。持续皮下胰岛素输注（CSII）的出现激发了人们对胰岛素治疗方案的思考。这些进展不仅共同推动了强化治疗作为糖尿病管理策略的发展，还使得能够制定研究方案来评估这种治疗对糖尿病慢性并发症的影响。
