Chemistry Department, Faculty of Science, Ain-Shams University, Cairo 11566, Egypt.
Chemistry Department, Faculty of Science, Ain-Shams University, Cairo 11566, Egypt.
Carbohydr Polym. 2015 Dec 10;134:687-94. doi: 10.1016/j.carbpol.2015.08.043. Epub 2015 Aug 20.
Bacterial cellulose (BC) and heparin-modified bacterial cellulose (HBC) were utilized to enhance the biocompatibility of highly thrombogenic PVC-based potassium and calcium membrane electrodes. Three types of membrane electrodes were prepared: (1) conventional PVC electrode (control), (2) PVC-based electrode sandwiched with bacterial cellulose membrane (BC-PVC), and (3) PVC-based electrode sandwiched with heparin-modified bacterial cellulose membrane (HBC-PVC). The potentiometric response characteristics of the modified potassium and calcium membrane electrodes (BC-PVC and HBC-PVC) were compared with those of the control PVC-based potassium and calcium selective electrode, respectively. Response characteristics of the modified membrane electrodes were comparable to the control PVC membrane electrode. The platelet adhesion investigations indicated that (BC) and (HBC) layers are less thrombogenic compared to PVC. Therefore, use of BC or HBC would enable the enhancement of the biocompatibility of PVC-based membrane electrodes for potassium and calcium while practically maintaining the overall electrochemical performance of the PVC sensing film.
细菌纤维素（BC）和肝素修饰的细菌纤维素（HBC）被用于提高高血栓形成的基于 PVC 的钾和钙膜电极的生物相容性。制备了三种类型的膜电极：（1）常规 PVC 电极（对照），（2）夹有细菌纤维素膜的基于 PVC 的电极（BC-PVC），和（3）夹有肝素修饰的细菌纤维素膜的基于 PVC 的电极（HBC-PVC）。分别比较了改性钾和钙膜电极（BC-PVC 和 HBC-PVC）的电位响应特性与对照 PVC 基钾和钙选择电极的特性。改性膜电极的响应特性与对照 PVC 膜电极相当。血小板黏附研究表明，（BC）和（HBC）层比 PVC 的血栓形成性更低。因此，使用 BC 或 HBC 可以提高基于 PVC 的钾和钙膜电极的生物相容性，同时实际保持 PVC 传感膜的整体电化学性能。
