类风湿关节炎和骨关节炎患者的脆性骨折与普通人群的比较

Fragility Fractures in Patients with Rheumatoid Arthritis and Osteoarthritis Compared with the General Population.

作者信息

Yamamoto Yuri, Turkiewicz Aleksandra, Wingstrand Hans, Englund Martin

机构信息

From the Department of Rehabilitation, Nagoya University Hospital, Nagoya, Japan; Orthopedics, Department of Clinical Sciences, Lund University; Epidemiology and Register Centre South, Skåne University Hospital, Region Skåne, Lund, Sweden; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts, USA.Y. Yamamoto, PT, Department of Rehabilitation, Nagoya University Hospital; A. Turkiewicz, MSc, Orthopedics, Department of Clinical Sciences, Lund University; H. Wingstrand, MD, PhD, Orthopedics, Department of Clinical Sciences, Lund University; M. Englund, MD, PhD, Orthopedics, Department of Clinical Sciences, Lund University, and Epidemiology and Register Centre South, Skåne University Hospital, and Clinical Epidemiology Research and Training Unit, Boston University School of Medicine.

出版信息

J Rheumatol. 2015 Nov;42(11):2055-8. doi: 10.3899/jrheum.150325. Epub 2015 Oct 1.

DOI:10.3899/jrheum.150325

PMID:26428208

Abstract

OBJECTIVE

To determine the rate ratios of hip and distal radius fractures in patients with rheumatoid arthritis (RA), hip osteoarthritis (OA), and knee OA.

METHODS

Cohort study using healthcare data (1998-2012) covering the entire population of the Skåne region of Sweden.

RESULTS

We found an increased rate of hip fracture in both female [standardized fracture rate ratio (SFR) 1.54, 95% CI 1.40-1.70] and male patients with RA (SFR 1.81, 95% CI 1.51-2.17). The hip fracture rate in female OA was reduced by 10-20%, and trochanteric fracture tended to have a higher rate ratio compared with the cervical.

CONCLUSION

The 50-80% increased rate of hip fracture adds to the total burden of RA while the shifted distribution of cervical/trochanteric fractures in OA is in support of subchondral bone alterations.

摘要