Cho Jae Yong, Sun Joo Sung, Sur Young Keun, Park Jin Sun, Kang Doo Kyoung
Department of Radiology, Ajou University School of Medicine, San 5, Woncheon-dong, Yongtong-gu, Suwon, Gyeonggi-do, 16499, Republic of Korea.
Department of Cardiology, Ajou University School of Medicine, San 5, Woncheon-dong, Yongtong-gu, Suwon, Gyeonggi-do, 16499, Republic of Korea.
Int J Cardiovasc Imaging. 2015 Dec;31 Suppl 2:187-96. doi: 10.1007/s10554-015-0772-1. Epub 2015 Oct 1.
We evaluated the relationship between coronary artery disease (CAD) and left ventricular mass (LVM) as measured by cardiac computed tomography (CT) in young adults ≤40 years of age. We retrospectively enrolled 490 consecutive individuals (383 males; mean age, 35.2 ± 4.4 years) who underwent cardiac CT. CAD was defined by the presence of any plaque detected by coronary CT angiography. Left ventricular (LV) function, including LVM, was automatically measured by a dedicated workstation. LVM and LVM index (LVMi) in patients with CT-detected CAD were compared to those of patients without CT-detected CAD. Logistic regression analysis was used to evaluate the relationship between cardiovascular risk factors and CAD. Fifty-five individuals had CT-detected CAD (11.2 %, 53 males). LVM measured by cardiac CT was 126.9 ± 30.0 g for males and 93.6 ± 20.9 g for females. LVM was higher (117.8 ± 30.8 vs. 133.6 ± 33.1 g, P < 0.001) in patients with CT-detected CAD compared with patients without CT-detected CAD. Obesity, hypertension, smoking, hypercholesterolemia, LVM and LVMi were predictors of CT-detected CAD. Body mass index (r = 0.237, P < 0.001) and systolic blood pressure (r = 0.281, P < 0.001) were positively correlated with LVM. In the multivariate analysis, LVM [odds ratio (OR) = 1.016] and LVMi (OR = 1.026) remained independent predictors of CAD. LVM and LVMi in patients with CT-detected CAD were higher than that of patients without CT-detected CAD. LVM and LVMi measured by cardiac CT were independent predictors of CAD.
我们评估了年龄≤40岁的年轻成年人中，通过心脏计算机断层扫描（CT）测量的冠状动脉疾病（CAD）与左心室质量（LVM）之间的关系。我们回顾性纳入了490例连续接受心脏CT检查的个体（383例男性；平均年龄35.2±4.4岁）。CAD由冠状动脉CT血管造影检测到的任何斑块定义。包括LVM在内的左心室（LV）功能由专用工作站自动测量。将CT检测到CAD的患者的LVM和LVM指数（LVMi）与未检测到CAD的患者进行比较。采用逻辑回归分析评估心血管危险因素与CAD之间的关系。55例个体经CT检测患有CAD（11.2%，53例男性）。通过心脏CT测量，男性的LVM为126.9±30.0g，女性为93.6±20.9g。与未检测到CAD的患者相比，CT检测到CAD的患者LVM更高（117.8±30.8 vs. 133.6±33.1g，P<0.001）。肥胖、高血压、吸烟、高胆固醇血症、LVM和LVMi是CT检测到CAD的预测因素。体重指数（r=0.237，P<0.001）和收缩压（r=0.281，P<0.001）与LVM呈正相关。在多变量分析中，LVM[比值比（OR）=1.016]和LVMi（OR=1.026）仍然是CAD的独立预测因素。CT检测到CAD的患者的LVM和LVMi高于未检测到CAD的患者。通过心脏CT测量的LVM和LVMi是CAD的独立预测因素。
