Farasat Tasnim, Sharif Saima, Naz Shagufta, Fazal Sabiha
Prof. Dr. Tasnim Farasat, Ph.D. Department of Zoology, Lahore College for Women University, Jail Road, Lahore, Pakistan.
Dr. Saima Sharif, Ph.D. Assistant Professor, Department of Zoology, Lahore College for Women University, Jail Road, Lahore, Pakistan.
Pak J Med Sci. 2015 Jul-Aug;31(4):991-4. doi: 10.12669/pjms.314.7063.
The present study was conducted to assess the serum concentration of creatinine and determine its relationship with potential risk factors of diabetes in Impaired Glucose tolerance subjects.
This cross sectional study was conducted on 100 IGT patients who attended Amin Hayat diabetic center in Lahore from January 2011- June 2011. Patients with age group 34-67 years, (both sexes) were included in the study. Different demographic parameters as age, BMI, WHR, B.P, personal history and socioeconomic status were recorded. Oral Glucose Tolerance Test was performed. The biochemical parameters including HbA1c, lipid profile, urea, uric acid, creatinine and bilirubin level were measured by chemistry analyzer.
A strong correlation between creatinine and HbA1c was observed. The level of creatinine was also significantly associated with age in IGT subjects. Creatinine is non-significantly correlated with Cholesterol, LDL-Chol and TG while negatively significantly associated with BMI, fasting blood glucose and HDL-Chol.
The present study concluded significant association of serum creatinine with HbA1c, BMI and HDL cholesterol.
本研究旨在评估糖耐量受损受试者的血清肌酐浓度，并确定其与糖尿病潜在危险因素之间的关系。
本横断面研究对2011年1月至2011年6月在拉合尔阿明·哈亚特糖尿病中心就诊的100例糖耐量受损患者进行。年龄在34 - 67岁的患者（男女不限）纳入研究。记录了不同的人口统计学参数，如年龄、体重指数、腰臀比、血压、个人病史和社会经济状况。进行了口服葡萄糖耐量试验。通过化学分析仪测量生化参数，包括糖化血红蛋白、血脂谱、尿素、尿酸、肌酐和胆红素水平。
观察到肌酐与糖化血红蛋白之间存在强相关性。在糖耐量受损受试者中，肌酐水平也与年龄显著相关。肌酐与胆固醇、低密度脂蛋白胆固醇和甘油三酯无显著相关性，而与体重指数、空腹血糖和高密度脂蛋白胆固醇呈负显著相关。
本研究得出结论，血清肌酐与糖化血红蛋白、体重指数和高密度脂蛋白胆固醇之间存在显著关联。
