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辅助立体定向体部放疗对胆囊癌的治疗潜力

Therapeutic Potential of Adjuvant Stereotactic Body Radiotherapy for Gallbladder Cancer.

作者信息

Mahadevan Anand, Dagoglu Nergiz, Tseng Jennifer F, Khawaja Khalid, Evenson Amy

机构信息

Department of Radiation Therapy, Beth Israel Deaconess Medical Center.

Department of Radiation Oncology, Istanbul University Istanbul Medical Faculty.

出版信息

Cureus. 2015 Aug 10;7(8):e299. doi: 10.7759/cureus.299.

Abstract

Surgical treatment remains the only curative treatment for gallbladder cancer. However, even after liver resection, locoregional failure seems to be a significant problem. While there is no Level I evidence, multiple studies have shown benefit for adjuvant radiation in high-risk patients. After extensive liver resection, tolerance to conventional chemoradiation may be limited by potential liver toxicity. Stereotactic body radiotherapy has been used safely and effectively in hepatobiliary malignancies. We present a case report, highlighting the potential therapeutic role of adjuvant stereotactic body radiotherapy (SBRT) for gallbladder cancer.

摘要

手术治疗仍然是胆囊癌唯一的治愈性治疗方法。然而,即使在肝切除术后,局部区域复发似乎仍是一个重大问题。虽然尚无一级证据,但多项研究表明辅助放疗对高危患者有益。广泛肝切除术后,传统放化疗的耐受性可能会受到潜在肝毒性的限制。立体定向体部放疗已安全有效地应用于肝胆恶性肿瘤。我们报告一例病例,强调辅助立体定向体部放疗(SBRT)对胆囊癌的潜在治疗作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a59/4572715/42a552e3425c/cureus-0007-000000000299-i01.jpg

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