Department of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226, USA.
Surg Oncol. 2013 Mar;22(1):61-7. doi: 10.1016/j.suronc.2012.12.001. Epub 2013 Jan 3.
Adjuvant treatment is not routine following resection for gallbladder cancer as most regimens have low response rates. In the palliative setting, recent advances have been made regarding combination chemotherapies and both gemcitabine/cisplatin and gemcitabine/oxaliplatin appear to be superior to single-agent 5FU, which has very little efficacy in this disease. There are isolated reports of dramatic responses to targeted monoclonal agents. The role of radiotherapy has recently been revisited, however, its effectiveness when patients are adequately surgically treated remains to be demonstrated.
胆囊癌切除术后通常不进行辅助治疗，因为大多数治疗方案的反应率较低。在姑息治疗环境中，联合化疗方面最近取得了一些进展，吉西他滨/顺铂和吉西他滨/奥沙利铂联合方案似乎优于单药 5FU，后者在这种疾病中疗效甚微。有一些关于针对单克隆抗体药物的显著反应的孤立报告。放疗的作用最近受到了重新审视，但是在充分手术治疗的患者中，其有效性仍有待证明。
