类护士细胞介导慢性淋巴细胞白血病患者对依鲁替尼的耐药性。 - Suppr

Nurse-like cells mediate ibrutinib resistance in chronic lymphocytic leukemia patients.

作者信息

Boissard F, Fournié J-J, Quillet-Mary A, Ysebaert L, Poupot M

机构信息

Centre de Recherches en Cancérologie de Toulouse, INSERM UMR1037, Université Toulouse III Paul-Sabatier, ERL 5294 CNRS, Toulouse, France.

Laboratoire d'Excellence 'TOUCAN', Programme Hospitalo-Universitaire en Cancérologie CAPTOR, Institut Carnot Lymphome CALYM, Pierre-Benite, France.

出版信息

Blood Cancer J. 2015 Oct 2;5(10):e355. doi: 10.1038/bcj.2015.74.

DOI:10.1038/bcj.2015.74

PMID:26430726

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4635187/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd0b/4635187/60318d3d8aa0/bcj201574f1.jpg

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Nurse-like cells mediate ibrutinib resistance in chronic lymphocytic leukemia patients.类护士细胞介导慢性淋巴细胞白血病患者对依鲁替尼的耐药性。

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Ibrutinib inhibits BCR and NF-κB signaling and reduces tumor proliferation in tissue-resident cells of patients with CLL.依鲁替尼抑制BCR和NF-κB信号传导，并减少慢性淋巴细胞白血病患者组织驻留细胞中的肿瘤增殖。

Blood. 2014 May 22;123(21):3286-95. doi: 10.1182/blood-2014-02-548610. Epub 2014 Mar 21.

BTK inhibition targets in vivo CLL proliferation through its effects on B-cell receptor signaling activity.BTK 抑制可通过其对 B 细胞受体信号活性的影响来靶向体内 CLL 增殖。

Leukemia. 2014 Mar;28(3):649-57. doi: 10.1038/leu.2013.358. Epub 2013 Nov 25.

Ibrutinib in relapsed chronic lymphocytic leukemia.伊布替尼用于复发的慢性淋巴细胞白血病

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Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia.伊布替尼治疗复发慢性淋巴细胞白血病的 BTK 靶点。

N Engl J Med. 2013 Jul 4;369(1):32-42. doi: 10.1056/NEJMoa1215637. Epub 2013 Jun 19.

Genomic and phenotypic characterization of nurse-like cells that promote drug resistance in chronic lymphocytic leukemia.促进慢性淋巴细胞白血病耐药的类淋巴母细胞的基因组和表型特征。

Leuk Lymphoma. 2011 Jul;52(7):1404-6. doi: 10.3109/10428194.2011.568078.

An interaction between hepatocyte growth factor and its receptor (c-MET) prolongs the survival of chronic lymphocytic leukemic cells through STAT3 phosphorylation: a potential role of mesenchymal cells in the disease.肝细胞生长因子与其受体（c-MET）之间的相互作用通过 STAT3 磷酸化延长慢性淋巴细胞白血病细胞的存活：间充质细胞在疾病中的潜在作用。

Haematologica. 2011 Jul;96(7):1015-23. doi: 10.3324/haematol.2010.029736. Epub 2011 Apr 12.

Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase.布鲁顿酪氨酸激酶选择性不可逆抑制剂的发现。

ChemMedChem. 2007 Jan;2(1):58-61. doi: 10.1002/cmdc.200600221.

Distinctive features of "nurselike" cells that differentiate in the context of chronic lymphocytic leukemia.在慢性淋巴细胞白血病背景下分化的“护士样”细胞的独特特征。

Blood. 2002 Feb 1;99(3):1030-7. doi: 10.1182/blood.v99.3.1030.

Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1.血液来源的类成纤维细胞通过基质细胞衍生因子-1保护慢性淋巴细胞白血病B细胞免于自发凋亡。

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Nurse-like cells mediate ibrutinib resistance in chronic lymphocytic leukemia patients.

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