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皮肤利什曼病——皮肤镜检查结果与冷冻疗法

Cutaneous Leishmaniasis - Dermoscopic Findings And Cryotherapy.

作者信息

Dobrev Hristo P, Nocheva Desislava G, Vuchev Dimitar Iv, Grancharova Rumyana D

机构信息

Department of Dermatology and Venereology

Department of Infectious Diseases, Parasitology and Tropical Medicine, Medical Faculty, Medical University, Plovdi

出版信息

Folia Med (Plovdiv). 2015 Jan-Mar;57(1):65-8. doi: 10.1515/folmed-2015-0021.

Abstract

We present a 60-year-old male patient who, three months after a holiday in Southern Greece, found a small 'pimple' on his back, which gradually got as big as a small walnut, the central part becoming ulcerated and scabby. Dermatological examination found an erythematous-to-livid nodular lesion on the right shoulder; it was 16 mm in diameter with central ulceration, covered with brownish crust which discharged pus-like secretion upon pressure. Microscope examination of Romanowsky-Giemsa stained lesion material detected amastigote forms of Leishmania tropica. The culture investigation and serological tests for leishmaniasis were negative. Dermoscopy of the lesion found the following features: erythema, hyperkeratosis, central ulceration covered with brownish crust, "yellow tears-like" structures and "white starburst-like" patterns, and various vascular structures (including dotted vessels, comma-shaped vessels, hairpin- and glomerular-like vessels). The patient was diagnosed with cutaneous leishmaniasis and underwent four cryotherapy sessions every other week with excellent therapeutic results - complete resolution of infiltrate with subsequent gentle hypopigmented scarring. In conclusion, dermoscopy is an easily accessible non-invasive method which can be useful for the diagnosis of cutaneous leishmaniasis. Cryotherapy is the treatment of choice for single skin lesions.

摘要

我们报告一名60岁男性患者,他在希腊南部度假三个月后,背部发现一个小“丘疹”,逐渐增大到小核桃大小,中央部分出现溃疡和结痂。皮肤科检查发现右肩部有一个从红斑到青紫色的结节性病变;直径16毫米,中央有溃疡,覆盖着褐色痂皮,按压时有脓性分泌物排出。对经罗曼诺夫斯基-吉姆萨染色的病变材料进行显微镜检查,发现了热带利什曼原虫的无鞭毛体形式。利什曼病的培养研究和血清学检测均为阴性。对该病变进行皮肤镜检查发现以下特征:红斑、角化过度、中央溃疡覆盖褐色痂皮、“黄色泪滴状”结构和“白色星爆状”图案,以及各种血管结构(包括点状血管、逗号状血管、发夹状和肾小球状血管)。该患者被诊断为皮肤利什曼病,每隔一周接受了四次冷冻治疗,治疗效果极佳——浸润完全消退,随后留下轻微色素减退性瘢痕。总之,皮肤镜检查是一种易于获得的非侵入性方法,可用于皮肤利什曼病的诊断。冷冻治疗是单个皮肤病变的首选治疗方法。

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