减肥手术对多囊卵巢综合征的影响：一项系统评价和荟萃分析。
The Impact of Bariatric Surgery on Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis.
作者信息
Skubleny Daniel, Switzer Noah J, Gill Richdeep S, Dykstra Mark, Shi Xinzhe, Sagle Margaret A, de Gara Christopher, Birch Daniel W, Karmali Shahzeer
机构信息
Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
出版信息
Obes Surg. 2016 Jan;26(1):169-76. doi: 10.1007/s11695-015-1902-5.
Bariatric surgery has been proven to be a successful management strategy for morbid obesity, but limited studies exist on its effect on polycystic ovary syndrome (PCOS). A comprehensive search of electronic databases was completed. Meta-analysis was performed on PCOS, hirsutism, and menstrual irregularity outcomes following bariatric surgery. Thirteen primary studies involving a total of 2130 female patients were identified. The incidence of PCOS preoperatively was 45.6 %, which significantly decreased to 6.8 % (P < 0.001) and 7.1 % (P < 0.0002) at 12-month follow-up and study endpoint, respectively. The incidences of preoperative menstrual irregularity and hirsutism both significantly decreased at 12-month and at study end follow-up. Bariatric surgery effectively attenuates PCOS and its clinical symptomatology including hirsutism and menstrual irregularity in severely obese women.
减肥手术已被证明是治疗病态肥胖的一种成功管理策略，但关于其对多囊卵巢综合征（PCOS）影响的研究有限。完成了对电子数据库的全面检索。对减肥手术后的PCOS、多毛症和月经不调结果进行了荟萃分析。确定了13项涉及总共2130名女性患者的初步研究。术前PCOS的发生率为45.6%，在12个月随访和研究终点时分别显著降至6.8%（P<0.001）和7.1%（P<0.0002）。术前月经不调和多毛症的发生率在12个月和研究结束随访时均显著降低。减肥手术有效地减轻了严重肥胖女性的PCOS及其临床症状，包括多毛症和月经不调。
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