Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55902, USA. Electronic address: https://twitter.com/KhushbooSGala.
Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55902, USA; Department of Internal Medicine, Boston University Medical Center, Harrison Avenue, Boston, MA 02111, USA. Electronic address: https://twitter.com/Wissam_Ghusn.
Gastrointest Endosc Clin N Am. 2024 Oct;34(4):765-779. doi: 10.1016/j.giec.2024.03.004. Epub 2024 Apr 16.
Obesity is a multi-factorial disease that is influenced by genetic, epigenetic, and environmental factors. Precision medicine is a practice wherein prevention and treatment strategies take individual variability into account. It involves using a variety of factors including deep phenotyping using clinical, physiologic, and behavioral characteristics, 'omics assays (eg, genomics, epigenomics, transcriptomics, and microbiomics among others), and environmental factors to devise practices that are individualized to subsets of patients. Personalizing the therapeutic modality to the individual can lead to enhanced effectiveness and tolerability. The authors review advances in precision medicine made in the field of bariatrics and discuss future avenues and challenges.
肥胖是一种多因素疾病，受遗传、表观遗传和环境因素的影响。精准医学是一种实践，其中预防和治疗策略考虑到个体的变异性。它涉及使用多种因素，包括使用临床、生理和行为特征的深度表型，“组学”分析（例如基因组学、表观基因组学、转录组学和微生物组学等）以及环境因素，以制定针对患者亚组的个体化实践。将治疗方式个性化可以提高疗效和耐受性。作者回顾了在减肥领域取得的精准医学进展，并讨论了未来的途径和挑战。
