减肥手术对肥胖女性不孕的影响：一项系统评价和荟萃分析。
Impact of bariatric surgery on infertility in obese women: a systematic review and meta-analysis.
作者信息
Makhsosi Behnam R, Ghobadi Pourya, Otaghi Masoumeh, Tardeh Zeinab
机构信息
Department of Laparoscopic Surgery, School of Medicine, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of General Surgery, School of Medicine, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
出版信息
Ann Med Surg (Lond). 2024 Oct 23;86(12):7042-7048. doi: 10.1097/MS9.0000000000002657. eCollection 2024 Dec.
BACKGROUND
The prevalence of obesity is increasing worldwide, with several consequences, including reduced fertility in both men and women. One of the ways to reduce weight is bariatric surgery. The aim of this systematic review and meta-analysis study was to evaluate the effectiveness of bariatric surgery on weight loss and subsequent improvement of fertility in obese infertile women.
METHODS
Several databases were searched using MESH terms to investigate the studies that evaluated the fertility rates after bariatric surgery in infertile obese women. Related data were obtained and analyzed using Stata software with a -value ≤0.05, which was considered as significant.
RESULTS
Of the 283 articles related to the purpose of this study, 9 articles, including 231 obese infertile women, were included in the study. BMI before surgery was 42.2 [95% CI= 39.2-45.2] and BMI after surgery was 31.9 (95% CI= 28.9-34.8), which shows the significance of weight loss after bariatric surgery. Conception rate after bariatric surgery weight loss was increased and was 67% (95% CI= 47-87%, -value <0.05).
CONCLUSIONS
Bariatric surgery had a significant effect on the reduction of BMI and subsequent significant improvement of fertility in obese infertile women.
背景
全球肥胖患病率呈上升趋势，带来了包括男性和女性生育力下降在内的诸多后果。减肥手术是减肥的方法之一。本系统评价和荟萃分析研究的目的是评估减肥手术对肥胖不孕女性体重减轻及随后生育力改善的有效性。
方法
使用医学主题词（MESH）检索多个数据库，以调查评估肥胖不孕女性减肥手术后生育率的研究。获取相关数据并使用Stata软件进行分析，P值≤0.05被视为具有统计学意义。
结果
在与本研究目的相关的283篇文章中，有9篇文章纳入研究，包括231名肥胖不孕女性。术前体重指数（BMI）为42.2[95%置信区间（CI）=39.2 - 45.2]，术后BMI为31.9（95%CI = 28.9 - 34.8），这表明减肥手术后体重减轻具有统计学意义。减肥手术后体重减轻后的受孕率有所提高，为67%（95%CI = 47 - 87%，P值<0.05）。
结论
减肥手术对肥胖不孕女性的BMI降低有显著影响，随后对生育力有显著改善。
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