Russell J C, Amy R M, Manickavel V, Dolphin P J
Department of Surgery, University of Alberta, Edmonton, Canada.
Arteriosclerosis. 1989 Jan-Feb;9(1):122-8. doi: 10.1161/01.atv.9.1.122.
Rats of the atherosclerosis-prone JCR:LA-corpulent strain were subjected to long-term low (0.5% wt/vol) or high (4% wt/vol) consumption of ethanol from 1 to 12 months of age. The corpulent rats are hyperphagic, obese, and insulin-resistant; exhibit a marked very low density lipoprotein hyperlipidemia; and develop both vascular and myocardial lesions while eating a normal rat chow. The total lipid profile of the rat sera showed only limited changes with ethanol consumption. There were also no significant effects on high density lipoprotein lipids. Ethanol consumption was associated with elevated fasting glucose concentrations in both lean and corpulent rats and a strong decrease in fasting insulin levels and pancreatic B-cell volume density in the hyperinsulinemic corpulent rats. The relative frequency of myocardial nodules of chronic inflammatory cells was increased in the ethanol-consuming rats, both lean and corpulent. In contrast, old organized lesions (scars) were absent in the ethanol-consuming corpulent rats. Thus, ethanol consumption had no major effect on serum lipids or lipoproteins in the corpulent rat but was associated with a reduction in insulin resistance and islet cell hyperplasia, with an associated decreased incidence of myocardial lesions.
将易患动脉粥样硬化的JCR:LA肥胖品系大鼠从1月龄至12月龄给予长期低剂量（0.5%重量/体积）或高剂量（4%重量/体积）的乙醇摄入。肥胖大鼠贪食、肥胖且胰岛素抵抗；表现出明显的极低密度脂蛋白高脂血症；在食用正常大鼠饲料时会出现血管和心肌病变。大鼠血清的总脂质谱仅显示乙醇摄入引起的有限变化。对高密度脂蛋白脂质也无显著影响。乙醇摄入与瘦大鼠和肥胖大鼠空腹血糖浓度升高以及高胰岛素血症肥胖大鼠空腹胰岛素水平和胰腺B细胞体积密度的强烈降低有关。在摄入乙醇的大鼠（包括瘦大鼠和肥胖大鼠）中，慢性炎性细胞心肌结节的相对频率增加。相比之下，摄入乙醇的肥胖大鼠中不存在陈旧性机化病变（瘢痕）。因此，乙醇摄入对肥胖大鼠的血清脂质或脂蛋白没有主要影响，但与胰岛素抵抗和胰岛细胞增生的降低有关，同时心肌病变的发生率也随之降低。
