Russell J C, Amy R M, Manickavel V, Dolphin P J, Epling W F, Pierce D, Boer D P
Department of Surgery, University of Alberta, Edmonton, Canada.
J Appl Physiol (1985). 1989 Apr;66(4):1649-55. doi: 10.1152/jappl.1989.66.4.1649.
The JCR:LA-corpulent rat is a congenic strain that, if homozygous for the cp gene, is obese with a very low-density lipoprotein hyperlipidemia and is insulin resistant. The male corpulent rats develop atherosclerotic lesions of the major arteries and myocardial lesions. Corpulent and lean male rats were induced through mild food restriction to run intensively (approximately 6,000 m/day) from 6 wk to 6 mo of age. Food restriction, especially when coupled with running, lowered all classes of lipids in the whole serum of corpulent rats. The principal changes in lipid concentrations were in the very low-density lipoprotein fraction. Food restriction caused a significant drop in fasting insulin levels of corpulent rats and decreased beta-cell hyperplasia. Both effects were more marked in the running animals. There was a significant decrease in myocardial lesion frequency in the food-restricted corpulent rats and an absence of lesions in the running rats. The results indicate that intensive physical activity can largely correct the lipid abnormalities and insulin resistance of this atherosclerosis-prone strain, and these changes are associated with inhibition of the disease process. However, moderate food restriction has similar effects, and the greater effects seen with intensive running may simply reflect an effectively more severe metabolic restriction in the presence of the exercise.
LA肥胖大鼠是一种近交系，若其cp基因纯合，则会出现肥胖、极低密度脂蛋白高脂血症并伴有胰岛素抵抗。雄性肥胖大鼠会出现主要动脉的动脉粥样硬化病变和心肌病变。对肥胖和瘦的雄性大鼠在6周龄至6月龄期间通过轻度食物限制诱导其进行高强度运动（约6000米/天）。食物限制，尤其是与运动相结合时，可降低肥胖大鼠全血清中各类脂质水平。脂质浓度的主要变化发生在极低密度脂蛋白部分。食物限制导致肥胖大鼠空腹胰岛素水平显著下降，并减少β细胞增生。这两种效应在运动的动物中更为明显。食物限制的肥胖大鼠心肌病变频率显著降低，而运动的大鼠则无病变。结果表明，高强度体育活动可在很大程度上纠正这种易患动脉粥样硬化品系的脂质异常和胰岛素抵抗，且这些变化与疾病进程的抑制相关。然而，适度的食物限制也有类似效果，高强度运动产生的更大效果可能仅仅反映了在运动存在的情况下更有效的严重代谢限制。
