Sritippho Thanun, Chotjumlong Pareena, Iamaroon Anak
Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand E-mail :
Asian Pac J Cancer Prev. 2015;16(15):6193-200. doi: 10.7314/apjcp.2015.16.15.6193.
Head and neck cancer, including oral cancer, is the sixth most common cancer in humans worldwide. More than 90% of oral cancers are of squamous cell carcinoma type. Recent studies have shown a strong relationship between human papillomavirus (HPV) infection and head and neck cancer, especially oropharyngeal squamous cell carcinoma (OPSCC) and oral squamous cell carcinoma (OSCC). Moreover, the incidence of HPV-related OSCC appears to be on the rise while HPV-unrelated OSCC tends to have stabilized in the past decades. p16, a tumor suppressor gene, normally functions as a regulator of the cell cycle. Upon infection with high-risk types of HPV (HR-HPV), particularly types 16, 18, 31, 33, 34, 35, 39, 51, 52, 56, 58, 59, 66, 68, and 70, the expression of p16 is aberrantly overexpressed. Therefore, the expression of p16 is widely used as a surrogate marker for HPV infection in head and neck cancer.
头颈癌，包括口腔癌，是全球人类中第六大常见癌症。超过90%的口腔癌为鳞状细胞癌类型。最近的研究表明，人乳头瘤病毒（HPV）感染与头颈癌，尤其是口咽鳞状细胞癌（OPSCC）和口腔鳞状细胞癌（OSCC）之间存在密切关系。此外，在过去几十年中，HPV相关的OSCC发病率似乎在上升，而HPV不相关的OSCC发病率趋于稳定。p16是一种肿瘤抑制基因，通常作为细胞周期的调节因子发挥作用。在感染高危型HPV（HR-HPV），特别是16、18、31、33、34、35、39、51、52、56、58、59、66、68和70型后，p16的表达异常上调。因此p16的表达被广泛用作头颈癌中HPV感染的替代标志物。
