Agarwal Ankit, Tijare Manisha, Saxena Anshul, Rubens Muni, Ahuja Rinky
Department of Oral Pathology and Microbiology, Peoples College of Dental Science and Research Center, Bhopal (MP), India E-mail :
Asian Pac J Cancer Prev. 2015;16(15):6439-44. doi: 10.7314/apjcp.2015.16.15.6439.
In India smokeless tobacco users account for 25.9% of total tobacco use, Gutkha being the most common form. This study evaluated the association between serum lipid profile and Gutkha use as an early diagnostic and/or prognostic indicator for oral submucous fibrosis (OSMF) and oral cancer (Oral Ca) in non-smokers and non-alcohol consumers.
A total of 163 participants were recruited from two sites in India. Participants were divided into four groups: individuals without any Gutkha chewing habit and without any oral lesions (control group), individuals with Gutkha chewing habit but without any oral lesions (GWL), patients with a confirmed clinical diagnosis of OSMF, and patients with a confirmed diagnosis of Oral Ca. Mixed linear modelling (MLM) was conducted to detect the change in mean serum lipid levels among four groups.
The sample consisted of 69% males and 31% females. Results of MLM show an inverse relationship between serum lipid levels in OSMF, and Oral Ca groups when compared to the control group.
The results of our study demonstrated that GWL, OSMF and Oral Ca patients had lower serum lipid levels. Low serum lipid levels could be an indicator of initial neoplastic changes in oral cancer.
在印度，无烟烟草使用者占烟草使用总量的25.9%，其中古特卡是最常见的形式。本研究评估了血清脂质谱与古特卡使用之间的关联，将其作为非吸烟者和非饮酒者口腔黏膜下纤维化（OSMF）和口腔癌（口腔癌）的早期诊断和/或预后指标。
从印度的两个地点招募了总共163名参与者。参与者被分为四组：没有任何古特卡咀嚼习惯且没有任何口腔病变的个体（对照组）、有古特卡咀嚼习惯但没有任何口腔病变的个体（GWL）、临床确诊为OSMF的患者以及确诊为口腔癌的患者。进行混合线性建模（MLM）以检测四组之间平均血清脂质水平的变化。
样本中男性占69%，女性占31%。MLM结果显示，与对照组相比，OSMF组和口腔癌组的血清脂质水平呈负相关。
我们的研究结果表明，GWL、OSMF和口腔癌患者的血清脂质水平较低。低血清脂质水平可能是口腔癌初始肿瘤变化的一个指标。
