Green Daniel J, Cotton Cary C, Dellon Evan S
Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Mayo Clin Proc. 2015 Oct;90(10):1400-10. doi: 10.1016/j.mayocp.2015.07.015.
Eosinophilic esophagitis (EoE) is an emerging clinicopathologic entity defined by abnormal esophageal eosinophilic infiltration. Management of this disease is hampered by limited understanding of etiologic and controllable risk factors. The aim of this systematic review was to determine the environmental risk factors for EoE. We searched the PubMed, Web of Science, and EMBASE databases from January 1, 1950, through June 30, 2015. To identify additional relevant studies, we hand searched bibliographies of included articles. We limited the review to articles using human subjects and consisting of case reports, case series, cross-sectional and cohort studies, and clinical trials. Nineteen articles discuss the risk of environmental exposures on EoE and indicate that environment plays a large role in the etiology of EoE. Seasonal, geographic, and climate-based differences in disease prevalence have been reported, but the exact mediators of this process, possibly aeroallergens that vary over time and from place to place, remain elusive.
嗜酸性粒细胞性食管炎（EoE）是一种新出现的临床病理实体，由食管嗜酸性粒细胞异常浸润所定义。对该疾病病因和可控危险因素的认识有限，阻碍了其治疗。本系统评价的目的是确定EoE的环境危险因素。我们检索了1950年1月1日至2015年6月30日期间的PubMed、科学网和EMBASE数据库。为了识别其他相关研究，我们手工检索了纳入文章的参考文献。我们将综述限制在使用人类受试者且包括病例报告、病例系列、横断面研究、队列研究和临床试验的文章。19篇文章讨论了环境暴露对EoE的风险，并表明环境在EoE的病因中起很大作用。已有关于疾病患病率的季节性、地理性和基于气候的差异的报道，但这一过程的确切介质，可能是随时间和地点而变化的空气变应原，仍然难以捉摸。
