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使用基于pH控制的光诱导电子转移（PET）敏化剂在光动力疗法中调节活性氧的产生。

Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser.

作者信息

Atchison Jordan, Kamila Sukanta, McEwan Conor, Nesbitt Heather, Davis James, Fowley Colin, Callan Bridgeen, McHale Anthony P, Callan John F

机构信息

Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT521SA, UK.

Engineering Research Institute, University of Ulster, Jordanstown, Northern Ireland BT37 0QB, UK.

出版信息

Chem Commun (Camb). 2015 Dec 7;51(94):16832-5. doi: 10.1039/c5cc07022h.

DOI:10.1039/c5cc07022h
PMID:26435142
Abstract

A new sensitiser (4) for use in photodynamic therapy (PDT) has been developed to enable control of ROS production as a function of pH. This pH dependent PDT behaviour was tested in HeLa cells and in SCID mice bearing human xenograft pancreatic cancer (BxPC-3) tumours.

摘要

一种用于光动力疗法（PDT）的新型敏化剂（4）已被开发出来，以实现根据pH值控制活性氧（ROS）的产生。这种依赖于pH值的光动力疗法行为在HeLa细胞和携带人异种移植胰腺癌（BxPC-3）肿瘤的重症联合免疫缺陷（SCID）小鼠中进行了测试。

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