State Key Laboratory of High-Performance Ceramics and Superfine Microstructure , Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050 , China.
University of Chinese Academy of Sciences , Beijing 100049 , China.
Nano Lett. 2018 Sep 12;18(9):5768-5774. doi: 10.1021/acs.nanolett.8b02409. Epub 2018 Jul 31.
X-ray-induced photodynamic therapy (X-PDT) has high depth of penetration and has considerable potential for applications in cancer therapy. Scintillators and heavy metals have been adopted to absorb X-rays and transmit the energy to photosensitizers. However, the low efficiency of converting X-rays to reactive oxygen species (ROS) presents a challenge for the use of X-PDT to cure cancer. In this study, a new method based on LiLuF:Ce@SiO@AgPO@Pt(IV) nanoparticles (LAPNP) is presented that could be used to enhance the curative effects of X-PDT. To make full use of the fluorescence produced by nanoscintillators (LiLuF:Ce), a cisplatin prodrug Pt(IV) was utilized as a sacrificial electron acceptor to increase the yield of hydroxyl radicals (·OH) by increasing the separation of electrons and holes in photosensitizers (AgPO). Additionally, cisplatin is produced upon the acceptance of electrons by Pt(IV) and further enhances the damage caused by ·OH. Via two-step amplification, the potential of LAPNP to enhance the effects of X-PDT has been demonstrated.
X 射线诱导光动力疗法（X-PDT）具有较高的穿透深度，在癌症治疗中有很大的应用潜力。闪烁体和重金属已被用于吸收 X 射线并将能量传递给光敏剂。然而，将 X 射线转化为活性氧物种（ROS）的效率低下，这对 X-PDT 治疗癌症的应用提出了挑战。在本研究中，提出了一种基于 LiLuF:Ce@SiO@AgPO@Pt(IV) 纳米粒子（LAPNP）的新方法，可用于增强 X-PDT 的治疗效果。为了充分利用纳米闪烁体（LiLuF:Ce）产生的荧光，利用顺铂前药 Pt(IV)作为牺牲电子受体，通过增加光敏剂（AgPO）中电子和空穴的分离，增加羟基自由基（·OH）的产率。此外，Pt(IV) 接受电子后会产生顺铂，进一步增强·OH 造成的损伤。通过两步放大，证明了 LAPNP 增强 X-PDT 效果的潜力。
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