Savage J R
MRC Radiobiology Unit, Chilton, Oxon, England.
Experientia. 1989 Jan 15;45(1):52-9. doi: 10.1007/BF01990452.
This paper attempts an update and comment upon some of the topics of chromosome aberration formation which Lea raised in Chapter VI of his classic work 'Actions of Radiations on living Cells'. Only the first nine sections of this chapter are covered, which deal primarily with the qualitative aspects of aberrations, their formation, classification and interrelationships. In commenting upon these topics, pertinent references are made to work with mammalian and human cells. Increased knowledge of the importance of DNA as a fundamental target and the integral part it plays in the complex structure of the chromosome, coupled with cellular techniques not available to these earlier workers necessitate some revision and modification of early ideas. However, inspite of the enormous accumulation of data and ideas since the original work was published in 1946, the foundation that these early workers laid is still very solid. Surprisingly, we are still puzzled by many of the problems that perplexed them.
本文尝试对 Lea 在其经典著作《辐射对活细胞的作用》第六章中提出的一些染色体畸变形成的主题进行更新和评论。本章仅涵盖前九节，主要涉及畸变的定性方面、其形成、分类及相互关系。在评论这些主题时，会引用与哺乳动物和人类细胞相关的研究。由于对 DNA 作为基本靶点的重要性以及它在染色体复杂结构中所起的不可或缺作用的认识不断增加，再加上早期研究人员无法获得的细胞技术，早期的观点有必要进行一些修订和修正。然而，尽管自 1946 年原著发表以来积累了大量的数据和观点，但这些早期研究人员奠定的基础仍然非常坚实。令人惊讶的是，我们仍然被许多曾困扰他们的问题所迷惑。
