Savage J R, Papworth D G
Mutat Res. 1982 Jul;95(1):7-18. doi: 10.1016/0027-5107(82)90062-8.
Two aspects of the relationship between Asymmetrical (A) and Symmetrical (S) radiation-induced chromosomal aberrations are considered in this paper. (1) Are A and S truly alternative modes of lesion interactions? Relative frequencies for chromatid-type and chromosome-type are examined, and new lymphocyte data using banding is used to look at this, and also for parallelism in chromosome participation of the two forms for various aberration categories. All the tests applied suggest that A and S are alternative interaction modes. (2) The long-term survival characteristics of A and S are discussed, and the differences in expected frequencies of derived S per surviving cell from chromosome-type and chromatid-types are stressed. Since many in vivo tissues have varying mixtures of potential chromatid and chromosome aberration-bearing target cells, ultimate cell survival and derived S frequencies may differ between tissues for the same absorbed dose. An Appendix gives Relative Corrected Lengths (RCL) for chromosomes of the human karyotype which should be used when testing the various exchange aberration categories for random chromosome participation.
本文考虑了不对称（A）和对称（S）辐射诱导的染色体畸变之间关系的两个方面。（1）A和S真的是损伤相互作用的替代模式吗？检查了染色单体型和染色体型的相对频率，并使用新的带型淋巴细胞数据来研究这一点，同时也研究了两种形式在各种畸变类别中染色体参与的平行性。所应用的所有测试都表明A和S是替代的相互作用模式。（2）讨论了A和S的长期存活特征，并强调了从染色体型和染色单体型存活细胞中衍生出的S的预期频率差异。由于许多体内组织具有不同混合比例的潜在携带染色单体和染色体畸变的靶细胞，对于相同的吸收剂量，不同组织的最终细胞存活率和衍生出的S频率可能会有所不同。附录给出了人类核型染色体的相对校正长度（RCL），在测试各种交换畸变类别中染色体随机参与情况时应使用该长度。
