Imperial College Healthcare NHS Trust, London, UK.
Department of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, Heidelberg, Germany.
Clin Microbiol Infect. 2015 Dec;21(12):1057-66. doi: 10.1016/j.cmi.2015.09.021. Epub 2015 Oct 3.
The various guidelines that are available for multidrug-resistant Gram-negative bacteria are useful, and contain broad areas of agreement. However, there are also important areas of controversy between the guidelines in terms of the details of applying contact precautions, single-room isolation and active surveillance cultures, differences in the approach to environmental cleaning and disinfection, and whether or not to perform staff and patient cohorting, healthcare worker screening or patient decolonization. The evidence-base is extremely limited and further research is urgently required to inform an evidence-based approach to multidrug-resistant Gram-negative bacteria prevention and control.
现有的针对多重耐药革兰氏阴性菌的各种指南很有用，并且包含广泛的共识领域。然而，在实施接触预防措施、单间隔离和主动监测培养、环境清洁和消毒方法的差异、是否进行员工和患者分组、医护人员筛查或患者去定植等方面，这些指南之间也存在重要的争议领域。证据基础极其有限，迫切需要进一步研究，为多重耐药革兰氏阴性菌的预防和控制提供循证方法。
