Kuroda Taisuke, Kinoshita Yuta, Niwa Hidekazu, Mizobe Fumiaki, Ueno Takanori, Kuwano Atsutoshi, Hatazoe Takashi, Hobo Seiji
Clinical Science and Pathobiology Division, Equine Research Institute, Japan Racing Association, Tochigi 320-0856, Japan.
Epizootic Research Center, Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
J Equine Sci. 2015;26(3):95-8. doi: 10.1294/jes.26.95. Epub 2015 Sep 30.
We report the first case of methicillin-resistant Staphylococcus aureus (MRSA) keratitis in a racehorse. A 5-year-old mare developed punctate keratitis after racing. The corneal ulcer continued to expand despite ophthalmic antimicrobial therapy. On day 6, a conjunctival graft surgery was performed. The mare was euthanized, following colitis and laminitis development on day 10. MRSA was isolated from the corneal swab taken at the time of euthanasia. Immunohistochemical analysis demonstrated gram-positive and anti-S. aureus monoclonal antibody-positive cocci infiltration of the corneal stroma; and a diagnosis of MRSA ulcerative keratitis was made. An ophthalmic antimicrobial against the isolated MRSA did not improve the ocular lesion. The MRSA strain was found to be staphylococcal cassette chromosome mec type II, a strain frequently isolated from humans in Japan.
我们报告了首例赛马感染耐甲氧西林金黄色葡萄球菌（MRSA）性角膜炎的病例。一匹5岁母马在比赛后出现点状角膜炎。尽管进行了眼部抗菌治疗，角膜溃疡仍继续扩大。在第6天，进行了结膜移植手术。在第10天出现结肠炎和蹄叶炎后，该母马被实施安乐死。从安乐死时采集的角膜拭子中分离出MRSA。免疫组织化学分析显示角膜基质中有革兰氏阳性且抗金黄色葡萄球菌单克隆抗体阳性的球菌浸润；从而确诊为MRSA溃疡性角膜炎。针对分离出的MRSA的眼部抗菌药物未能改善眼部病变。发现该MRSA菌株为葡萄球菌盒式染色体mec II型，这是一种在日本经常从人类分离出的菌株。
