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2
A Brief Review on Diagnosis of Foot-and-Mouth Disease of Livestock: Conventional to Molecular Tools.家畜口蹄疫诊断简述：从传统方法到分子工具
Vet Med Int. 2011;2011:905768. doi: 10.4061/2011/905768. Epub 2011 Jul 6.
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Vet Immunol Immunopathol. 2010 May 15;135(1-2):164-171. doi: 10.1016/j.vetimm.2009.11.008. Epub 2009 Nov 24.
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整合素β6（ITGB6）受体基因单核苷酸多态性（SNP，rs136500299）的杂合性可能会影响杂交公牛对口蹄疫感染的易感性。

Heterozygosity at the SNP (rs136500299) of ITGB6 receptor gene possibly influences the susceptibility among crossbred bull to foot and mouth disease infection.

作者信息

Singh Rani, Deb Rajib, Singh Umesh, Raja T V, Alex Rani, Kumar Sushil, Chakraborti Soumendu, Alyethodi Rafeeque R, Sharma Sheetal, Sengar Gyanendra

机构信息

Molecular Genetics Laboratory, Central Institute for Research on Cattle, Indian Council of Agricultural Research, Meerut, 250 001 Uttar Pradesh India.

Indian Veterinary Research Institute, Izatnagar, 243122 Uttar Pradesh India.

出版信息

Virusdisease. 2015 Jun;26(1-2):48-54. doi: 10.1007/s13337-015-0249-9. Epub 2015 Mar 28.

DOI:10.1007/s13337-015-0249-9
PMID:26436121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4585059/
Abstract

Zebu (Bos indicus) cattle are known to be resistant against foot and mouth disease virus (FMDV) compared to taurine (Bos taurus). To understand the susceptibility of two cattle species to FMDV infection in terms of viral receptors, the present study reports the cloning, characterization and sequence analysis of Zebu ITGB6 gene. The complete CDS of zebu ITGB6 was 2367 basepair in length with 788 amino acid residues. The zebu integrin shares common structural and functional elements with taurine and other species. We identified an amino substitution (S665 to F665) presents in ITGB6 gene among zebu and taurine as SNP (rs136500299). Further, we determined and compared the structural differences of ITGB6 receptor gene among zebu and taurine species. To elucidate the influence of the SNP on the susceptibility of cattle to FMDV infection, a tetra ARMS PCR based genetic screening was performed among Zebu and crossbred cattle. Our observation revealed that, the targeted SNP are strongly (P < 0.05) associated with FMD susceptibility among Frieswal (HF X Sahiwal) crossbred cattle.

摘要

与普通牛（Bos taurus）相比，瘤牛（Bos indicus）已知对口蹄疫病毒（FMDV）具有抗性。为了从病毒受体角度了解这两种牛对FMDV感染的易感性，本研究报告了瘤牛ITGB6基因的克隆、特征分析和序列分析。瘤牛ITGB6的完整编码序列（CDS）长度为2367个碱基对，有788个氨基酸残基。瘤牛整合素与普通牛及其他物种具有共同的结构和功能元件。我们鉴定出瘤牛和普通牛的ITGB6基因中存在一个氨基酸替换（S665变为F665），作为单核苷酸多态性（SNP，rs136500299）。此外，我们确定并比较了瘤牛和普通牛物种间ITGB6受体基因的结构差异。为了阐明该SNP对牛FMDV感染易感性的影响，在瘤牛和杂交牛中进行了基于四引物扩增受阻突变系统（tetra ARMS）PCR的基因筛查。我们的观察结果显示，在弗里兹瓦尔（HF×萨希瓦尔）杂交牛中，靶向SNP与FMD易感性显著相关（P < 0.05）。