[血清中丝氨酸蛋白酶的热稳定和酸稳定抑制剂抑制有丝分裂原刺激的淋巴细胞转化的特性]
[Property of a heat- and acid-stable inhibitor of serine proteinases from the blood serum to inhibit lymphcyte transformation stimulated by mitogens].
作者信息
Baranova F S, Ogloblina O G, Popova L K, Platonova L V, Berman A A
出版信息
Biull Eksp Biol Med. 1978 May;85(5):569-72.
Thermo- and acid-stable serine proteases inhibitor from the rabbit blood serum (TASPI) was shown to inhibit the human peripheral blood lymphocytes transformation stimulated by phytohemagglutinin (PHA) or concanavalin A. The extent of inhibition depended on the concentration of the preparation and its specific activity. The maximal inhibition of lymphocytes proliferation constituted 50 to 70%. TASPI displayed no cytotoxic activity. Considerably more effective inhibition was demonstrated by TASPI addition to the culture medium 24 hours after the addition of PHA. The antiprotease activity of crude human serum and that inactivated under different conditions is described. The results obtained suggest the participation of TASPI in the control of biological activity of the lymphoid tissue cells.
已证明，来自兔血清的热稳定和酸稳定丝氨酸蛋白酶抑制剂（TASPI）可抑制由植物血凝素（PHA）或刀豆球蛋白A刺激的人外周血淋巴细胞转化。抑制程度取决于制剂的浓度及其比活性。淋巴细胞增殖的最大抑制率为50%至70%。TASPI无细胞毒性活性。在加入PHA 24小时后向培养基中添加TASPI，显示出更有效的抑制作用。描述了粗制人血清及其在不同条件下失活后的抗蛋白酶活性。所得结果表明TASPI参与了淋巴组织细胞生物活性的控制。
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