手性钯配合物催化的串联芳基化/烯丙基烷基化反应实现二烯的对映选择性 1,2-双官能化反应。
Enantioselective 1,2-Difunctionalization of Dienes Enabled by Chiral Palladium Complex-Catalyzed Cascade Arylation/Allylic Alkylation Reaction.
机构信息
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
Collaborative Innovation Center of Chemical Science and Engineering , Tianjin 300072, China.
出版信息
J Am Chem Soc. 2015 Oct 28;137(42):13476-9. doi: 10.1021/jacs.5b08734. Epub 2015 Oct 15.
A Pd-catalyzed highly enantioselective three-component coupling of 1,3-dienes with aryl iodines and sodium dialkyl malonates has been successfully established by using a H8-BINOL-based phosphoramidite ligand. This reaction proceeded via a Pd-catalyzed cascade arylation and asymmetric allylic alkylation reaction, providing an efficient strategy for the enantioselective 1,2-difunctionalization of 1,3-dienes.
通过使用基于 H8-BINOL 的手性膦酰胺配体，成功建立了一种 Pd 催化的高对映选择性的 1,3-二烯与芳基碘和二烷基丙二酸二钠盐的三组分偶联反应。该反应通过 Pd 催化的级联芳基化和不对称烯丙基烷基化反应进行，为 1,3-二烯的对映选择性 1,2-双官能化提供了一种有效的策略。
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