Notch活性的非配体依赖机制。
Ligand-Independent Mechanisms of Notch Activity.
作者信息
Palmer William Hunt, Deng Wu-Min
机构信息
Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA; Current Address: Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK.
Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA.
出版信息
Trends Cell Biol. 2015 Nov;25(11):697-707. doi: 10.1016/j.tcb.2015.07.010. Epub 2015 Oct 1.
Abstract
Interaction between the Notch receptor and Delta-Serrate-Lag2 (DSL) ligands is generally deemed to be the starting point of the Notch signaling cascade, after which, Notch is cleaved and the intracellular domain acts as a transcriptional coactivator. By contrast, Notch protein can become activated independent of ligand stimulus through recently identified endosomal trafficking routes as well as through aberrant regulation of Notch components during Notch trafficking, ubiquitination, and degradation. In this review, we summarize genes implicated in ligand-independent Notch activity and remark on the mechanisms by which this process could occur.
摘要
Notch受体与Delta-Serrate-Lag2（DSL）配体之间的相互作用通常被认为是Notch信号级联反应的起始点，在此之后，Notch被切割，其细胞内结构域作为转录共激活因子发挥作用。相比之下，Notch蛋白可以通过最近发现的内体运输途径以及在Notch运输、泛素化和降解过程中Notch组分的异常调节，独立于配体刺激而被激活。在本综述中，我们总结了与非配体依赖性Notch活性相关的基因，并对这一过程可能发生的机制进行了阐述。
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