Chelluboina Bharath, Dinh Dzung H, Veeravalli Krishna Kumar
Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, 1 Illini Drive, Peoria, IL, 61605, USA.
Department of Neurosurgery, University of Illinois College of Medicine at Peoria, 530 N.E. Glen Oak Ave., Peoria, IL, 61637, USA.
Stem Cell Res Ther. 2015 Oct 5;6:191. doi: 10.1186/s13287-015-0186-y.
Evidence suggests that transdifferentiation of mesenchymal stem cells (MSCs) into various neuronal cells contributes to functional recovery after experimental spinal cord injury. Qiu et al. have recently published an exciting article in Stem Cell Research & Therapy demonstrating the transdifferentiation of already differentiated MSCs that contributes to remyelination of injured/regenerating axons, and thereby to functional recovery of spinal cord injured animals. The authors highlight the importance of interaction between neurotrophin-3 and tropomyosin receptor kinase C for the observed effects. This study provided important evidence that manipulation of rat bone marrow-derived MSCs before transplantation could enhance the therapeutic benefit of cell-based treatment.
有证据表明，间充质干细胞（MSCs）向各种神经元细胞的转分化有助于实验性脊髓损伤后的功能恢复。邱等人最近在《干细胞研究与治疗》上发表了一篇令人兴奋的文章，证明已分化的MSCs的转分化有助于损伤/再生轴突的髓鞘再生，从而促进脊髓损伤动物的功能恢复。作者强调了神经营养因子-3与原肌球蛋白受体激酶C之间的相互作用对于所观察到的效应的重要性。这项研究提供了重要证据，表明移植前对大鼠骨髓来源的MSCs进行操作可以增强基于细胞的治疗的益处。
