Timur H, Kokanali M K, Inal H A, Tuzluoglu D, Yilmaz N
Department of Reproductive Endocrinology, Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
Department of Gynecology and Obstetrics, Konya Education and Research Hospital, Konya, Turkey.
Andrologia. 2016 Aug;48(6):626-30. doi: 10.1111/and.12491. Epub 2015 Oct 6.
Our aim was to compare peripheral blood and seminal fluid serum amyloid A (SAA) protein levels in men classified on the basis of sperm concentration and investigate whether SAA protein is an important marker of male infertility. A total of 74 first-attempt IVF male partners of infertile couples classified as azoospermic (n = 25), oligozoospermic (n = 25) and normozoospermic group (n = 24) were recruited for this cross-sectional study. There was no difference with respect to age, BMI, infertility period and smoking ratio. No difference in haematologic parameters including white blood cell count, neutrophil ratio, lymphocyte ratio, neutrophil-to-lymphocyte ratio and blood SAA level was found between the groups. Seminal fluid SAA level was 17.85 ± 2.21 ng ml(-1) in azoospermics, 16.13 ± 3.58 ng ml(-1) in oligozoospermics and 15.67 ± 4.77 ng ml(-1) in normozoospermics, showing no significant difference. Seminal SAA level was found to be not correlated with blood SAA levels. Therefore, we could not find any associations between these parameters at all. However, further studies with more participants are needed to address the exact action of SAA on spermatogenesis.
我们的目的是比较根据精子浓度分类的男性外周血和精液中血清淀粉样蛋白A（SAA）的水平，并研究SAA蛋白是否为男性不育的重要标志物。本横断面研究招募了74名首次接受体外受精的不育夫妇男性伴侣，分为无精子症组（n = 25）、少精子症组（n = 25）和正常精子症组（n = 24）。在年龄、体重指数、不孕时间和吸烟率方面无差异。各组间血液学参数包括白细胞计数、中性粒细胞比例、淋巴细胞比例、中性粒细胞与淋巴细胞比例及血液SAA水平均无差异。无精子症患者精液SAA水平为17.85±2.21 ng/ml，少精子症患者为16.13±3.58 ng/ml，正常精子症患者为15.67±4.77 ng/ml，差异无统计学意义。精液SAA水平与血液SAA水平不相关。因此，我们根本未发现这些参数之间存在任何关联。然而，需要更多参与者进行进一步研究，以阐明SAA对精子发生的确切作用。
