Cito Gianmartin, Coccia Maria Elisabetta, Picone Rita, Cocci Andrea, Russo Giorgio Ivan, Cai Tommaso, Bencini Giulia, Fucci Rossella, Micelli Elisabetta, Criscuoli Luciana, Bertocci Francesco, Borrani Elena, Serni Sergio, Carini Marco, Natali Alessandro
Department of Urology, Careggi Hospital, University of Florence, Florence, Italy.
Assisted Reproductive Technology Centre, Careggi Hospital, University of Florence, Florence, Italy.
World J Mens Health. 2019 Sep;37(3):347-354. doi: 10.5534/wjmh.180110. Epub 2019 Feb 18.
The relationship between male systemic inflammation and fertility seems intriguing, but no data about its impact on the assisted reproductive technology outcomes has been reported. Here, we aimed to evaluate the prognostic role of male systemic inflammatory parameters in intracytoplasmic sperm injection (ICSI) outcomes prediction, in couples undergoing an ovum donation program.
From January 2016 to December 2017, one hundred-ten couples were considered for this cross-sectional study. Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-eosinophil ratio (MER), platelet-to-lymphocyte ratio (PLR), seminal parameters, fertilization rate (FR), cleavage rate (CR), pregnancy rate (PR) were evaluated. Male patients were divided into Group A with FR ≤70%, Group B with FR >70%.
Overall, FR was 74.5%, CR 90.9%, PR 41.8%. Group A included 43 patients, Group B 67 men. Group A showed a median NLR of 1.55, PLR of 106.09, MER of 2.33. Group B reported a median NLR of 1.64, PLR 109.0, MER 2.76. We found no statistically differences between two groups with respect to NLR, PLR, MER (p=0.90, p=0.70, p=0.96, respectively). The age-adjusted linear regression analysis demonstrated only a relationship between NLR and sperm motility count (r=-0.02; p<0.05). Using the univariate logistic regression analysis, we found no significant associations.
We did not find any relationship between ICSI outcomes and male inflammation parameters.
男性全身炎症与生育能力之间的关系似乎很有趣，但尚无关于其对辅助生殖技术结局影响的数据报道。在此，我们旨在评估男性全身炎症参数在卵母细胞捐赠计划夫妇的卵胞浆内单精子注射（ICSI）结局预测中的预后作用。
2016年1月至2017年12月，对110对夫妇进行了这项横断面研究。评估了中性粒细胞与淋巴细胞比率（NLR）、单核细胞与嗜酸性粒细胞比率（MER）、血小板与淋巴细胞比率（PLR）、精液参数、受精率（FR）、卵裂率（CR）、妊娠率（PR）。男性患者分为A组（FR≤70%）和B组（FR>70%）。
总体而言，FR为74.5%，CR为90.9%，PR为41.8%。A组包括43例患者，B组包括67例男性。A组的NLR中位数为1.55，PLR为106.09，MER为2.33。B组的NLR中位数为1.64，PLR为109.0，MER为2.76。我们发现两组在NLR、PLR、MER方面无统计学差异（p分别为0.90、0.70、0.96）。年龄调整线性回归分析仅显示NLR与精子活力计数之间存在关系（r = -0.02；p<0.05）。使用单因素逻辑回归分析，我们未发现显著关联。
我们未发现ICSI结局与男性炎症参数之间存在任何关系。
