Mori N, Takamori Y
Department of Medical Biology and Hygiene, Radiation Center of Osaka Prefecture, Osaka.
Radiat Res. 1989 Jan;117(1):35-46.
The kinetics of the appearance of potentially leukemic cells (PoLCs) for radiation-induced lymphoma in NFS mice was investigated by the opposite sex (male----female) transplantation assay. The origin of the cells of the lymphomas that developed in the host was decided by sex chromosome markers. The bone marrow and the spleen cells collected from mice 30 days after fractionated irradiation (1.7 Gy X 4) gave rise, upon transfer to 4-Gy-irradiated hosts, to tumors of either donor or host origin. Most tumors of donor origin were thymine-1-negative (Thy-1-) and surface immunoglobulin negative and classified as nonthymic lymphoma, while the tumors of host origin were mainly Thy-1-positive thymic lymphoma. In contrast, neither the bone marrow nor the thymus contained any PoLCs for thymic lymphoma 30 days after split-dose irradiation. These results indicate that PoLCs for Thy-1-lymphoma were induced in the bone marrow and spleens of NFS mice by the split-dose regimen which developed exclusively T-cell lymphomas in the absence of cell grafting.
通过异性（雄性→雌性）移植试验，研究了NFS小鼠辐射诱导淋巴瘤中潜在白血病细胞（PoLCs）出现的动力学。宿主中发生的淋巴瘤细胞起源由性染色体标记决定。分次照射（1.7 Gy×4）30天后从小鼠收集的骨髓和脾细胞，转移至接受4 Gy照射的宿主后，可引发供体或宿主来源的肿瘤。大多数供体来源的肿瘤胸腺嘧啶-1阴性（Thy-1-）且表面免疫球蛋白阴性，分类为非胸腺淋巴瘤，而宿主来源的肿瘤主要是Thy-1阳性胸腺淋巴瘤。相比之下分剂量照射30天后，骨髓和胸腺均未含有任何用于胸腺淋巴瘤的PoLCs。这些结果表明，分剂量方案在NFS小鼠的骨髓和脾脏中诱导出了用于Thy-1淋巴瘤的PoLCs，该方案在无细胞移植的情况下专门产生T细胞淋巴瘤。
