Tsui Judith I, Cheng Debbie M, Quinn Emily, Bridden Carly, Merlin Jessica S, Saitz Richard, Samet Jeffrey H
Section of General Internal Medicine, Department of Medicine, University of Washington School of Medicine and Harborview Hospital, 401 Broadway, 5th Floor, Seattle, WA, 98122, USA.
Clinical Addiction Research and Education (CARE) Unit, Section of General Internal Medicine, Department of Medicine, Boston University and Boston Medical Center, Boston, MA, USA.
AIDS Behav. 2016 Mar;20(3):583-9. doi: 10.1007/s10461-015-1206-8.
Pain has been associated with increased risk for mortality in some studies. We analyzed data from a cohort study [HIV-longitudinal interrelationships of viruses and ethanol (HIV-LIVE)] of HIV-infected persons with alcohol use disorders enrolled 2001-2003 to explore whether reporting moderate or greater pain interference was associated with mortality. The main independent variable was pain that at least moderately interfered with work based on a single question from the SF-12. Primary analyses dichotomized at "moderately" or above. Cox proportional hazards models assessed the association between pain interference and death adjusting for demographics, substance use, CD4 count, HIV viral load and co-morbidities. Although significant in unadjusted models (HR = 1.58 (95 % CI 1.03-2.41; p value = 0.04)), after adjusting for confounders, ≥moderate pain interference was not associated with an increased risk of death [aHR = 1.30 (95 % CI 0.81-2.11, p value = 0.28)]. Among HIV-infected persons with alcohol use disorders, we did not detect a statistically significant independent association between pain interference and risk of death after adjustment for potential confounders.
在一些研究中，疼痛与死亡风险增加有关。我们分析了一项队列研究[HIV-病毒与乙醇的纵向相互关系（HIV-LIVE）]的数据，该研究纳入了2001年至2003年患有酒精使用障碍的HIV感染者，以探讨报告中度或更严重的疼痛干扰是否与死亡率相关。主要自变量是基于SF-12中的一个问题，即至少中度干扰工作的疼痛。初步分析在“中度”及以上进行二分法划分。Cox比例风险模型评估了疼痛干扰与死亡之间的关联，并对人口统计学、物质使用、CD4细胞计数、HIV病毒载量和合并症进行了调整。尽管在未调整的模型中具有显著性（HR = 1.58（95%CI 1.03 - 2.41；p值 = 0.04）），但在调整混杂因素后，≥中度疼痛干扰与死亡风险增加无关[aHR = 1.30（95%CI 0.81 - 2.11，p值 = 0.28）]。在患有酒精使用障碍的HIV感染者中，在调整潜在混杂因素后，我们未检测到疼痛干扰与死亡风险之间存在统计学上显著的独立关联。
