Li Youjun, Zhu Yahui, Prochownik Edward V
College of Life Sciences, Wuhan University, Wuhan 430072, China; Medical Research Institute, Wuhan University, Wuhan 430071, China.
College of Life Sciences, Wuhan University, Wuhan 430072, China.
RNA Dis. 2016;3(3). doi: 10.14800/rd.1330. Epub 2016 May 30.
microRNAs (miRs) are small, non-coding RNAs, which play crucial roles in the development and progression of human cancer. Given that miRs are stable, easy to synthetize and readily introduced into cells, they have been viewed as having potential therapeutic benefit in cancer. c-Myc (Myc) is one of the most commonly deregulated oncogenic transcription factors and has important roles in the pathogenesis of cancer, thus making it an important, albeit elusive therapeutic target. Here we review the miRs that have been identified as being both positive and negative targets for Myc and how these participate in the complex phenotypes that arise as a result of Myc-driven transformation. We also discussseveral recent reports of Myc-synthetic lethal interactions with miRs.These highlight the importance and complexity of miRs in Myc-mediated biological functions and the opportunities for Myc-driven human cancer therapies.
微小RNA（miRs）是一类小的非编码RNA，在人类癌症的发生和发展中起着关键作用。鉴于miRs稳定、易于合成且易于导入细胞，它们被认为在癌症治疗中具有潜在益处。c-Myc（Myc）是最常失调的致癌转录因子之一，在癌症发病机制中起重要作用，因此它是一个重要但难以捉摸的治疗靶点。在这里，我们综述了已被确定为Myc的正向和负向靶点的miRs，以及这些miRs如何参与由Myc驱动的转化所产生的复杂表型。我们还讨论了最近几篇关于Myc与miRs合成致死相互作用的报道。这些报道突出了miRs在Myc介导的生物学功能中的重要性和复杂性，以及Myc驱动的人类癌症治疗的机会。
