Cetin Elif Hande Ozcan, Cetin Mehmet Serkan, Canpolat Uğur, Aydin Selahattin, Topaloglu Serkan, Aras Dursun, Aydogdu Sinan
Türkiye Yuksek Ihtisas Education & Research Hospital, Cardiology Department, Ankara, Turkey.
Biomark Med. 2015;9(10):967-77. doi: 10.2217/bmm.15.74. Epub 2015 Oct 6.
We investigated the predictive value of monocyte count to HDL ratio (M/H ratio) for stent thrombosis (ST) in ST elevation myocardial infarction (STEMI).
PATIENTS & METHODS: 1170 STEMI patients treated with primary PCI were followed-up for a median of 37.2 months.
During follow-up, 112 patients were diagnosed as 'definite' ST. The rate of ST was significantly highest in the third M/H ratio tertile. In Cox regression analysis, adjusted for other factors, having an M/H ratio in third tertile had a 2.2-fold increased risk of ST. Kaplan-Meier analysis revealed the higher occurrence of ST in the third tertile compared with others (p <0.001).
M/H ratio as a novel marker of inflammation seemed to be an independent predictor of ST in STEMI patients.
我们研究了单核细胞计数与高密度脂蛋白比值（M/H比值）对ST段抬高型心肌梗死（STEMI）患者支架内血栓形成（ST）的预测价值。
1170例行直接经皮冠状动脉介入治疗（PCI）的STEMI患者接受了中位时间为37.2个月的随访。
随访期间，112例患者被诊断为“明确的”ST。ST发生率在M/H比值三分位数的第三组中显著最高。在多因素Cox回归分析中，校正其他因素后，处于M/H比值三分位数第三组的患者发生ST的风险增加2.2倍。Kaplan-Meier分析显示，与其他组相比，第三组ST的发生率更高（p<0.001）。
M/H比值作为一种新的炎症标志物，似乎是STEMI患者ST的独立预测因子。
