单核细胞/高密度脂蛋白胆固醇比值可预测ST段抬高型心肌梗死直接经皮冠状动脉介入治疗后的明确支架内血栓形成。
Monocyte/HDL-cholesterol ratio predicts the definite stent thrombosis after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction.
作者信息
Cetin Elif Hande Ozcan, Cetin Mehmet Serkan, Canpolat Uğur, Aydin Selahattin, Topaloglu Serkan, Aras Dursun, Aydogdu Sinan
机构信息
Türkiye Yuksek Ihtisas Education & Research Hospital, Cardiology Department, Ankara, Turkey.
出版信息
Biomark Med. 2015;9(10):967-77. doi: 10.2217/bmm.15.74. Epub 2015 Oct 6.
AIM
We investigated the predictive value of monocyte count to HDL ratio (M/H ratio) for stent thrombosis (ST) in ST elevation myocardial infarction (STEMI).
PATIENTS & METHODS: 1170 STEMI patients treated with primary PCI were followed-up for a median of 37.2 months.
RESULTS
During follow-up, 112 patients were diagnosed as 'definite' ST. The rate of ST was significantly highest in the third M/H ratio tertile. In Cox regression analysis, adjusted for other factors, having an M/H ratio in third tertile had a 2.2-fold increased risk of ST. Kaplan-Meier analysis revealed the higher occurrence of ST in the third tertile compared with others (p <0.001).
CONCLUSION
M/H ratio as a novel marker of inflammation seemed to be an independent predictor of ST in STEMI patients.
目的
我们研究了单核细胞计数与高密度脂蛋白比值（M/H比值）对ST段抬高型心肌梗死（STEMI）患者支架内血栓形成（ST）的预测价值。
患者与方法
1170例行直接经皮冠状动脉介入治疗（PCI）的STEMI患者接受了中位时间为37.2个月的随访。
结果
随访期间，112例患者被诊断为“明确的”ST。ST发生率在M/H比值三分位数的第三组中显著最高。在多因素Cox回归分析中，校正其他因素后，处于M/H比值三分位数第三组的患者发生ST的风险增加2.2倍。Kaplan-Meier分析显示，与其他组相比，第三组ST的发生率更高（p<0.001）。
结论
M/H比值作为一种新的炎症标志物，似乎是STEMI患者ST的独立预测因子。
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