Sener A, Lebrun P, Blachier F, Malaisse W J
Laboratory of Experimental Medicine, Brussels Free University, Belgium.
Biochem Pharmacol. 1989 Jan 15;38(2):327-30. doi: 10.1016/0006-2952(89)90044-0.
Agmatine causes a concentration-related (0.1-1.0 mM) stimulation of insulin secretion by rat pancreatic islets exposed to D-glucose (5.6-11.1 mM) but, like L-arginine, fails to affect insulin release either in the absence of glucose or at a high concentration (16.7 mM) of the hexose. Agmatine, which accumulates in islet cells, also stimulates 45Ca net uptake by the islets. The secretory response to agmatine represents a delayed process. It is enhanced by theophylline and suppressed by antimycin A or the absence of extracellular Ca2+. The insulinotropic action of agmatine is compatible with the view that endogenously formed polyamines may play a role in the secretory response of islet cells to L-arginine.
胍丁胺可使暴露于D-葡萄糖（5.6 - 11.1 mM）的大鼠胰岛的胰岛素分泌产生浓度相关（0.1 - 1.0 mM）的刺激作用，但与L-精氨酸一样，在无葡萄糖或高浓度（16.7 mM）己糖存在时，对胰岛素释放没有影响。在胰岛细胞中蓄积的胍丁胺也可刺激胰岛对45Ca的净摄取。对胍丁胺的分泌反应是一个延迟过程。茶碱可增强该反应，抗霉素A或细胞外Ca2+缺失则可抑制该反应。胍丁胺的促胰岛素作用与内源性形成的多胺可能在胰岛细胞对L-精氨酸的分泌反应中起作用这一观点相符。
