First School of Clinical Medicine, Lanzhou University, Lanzhou 730000.
Clinical Laboratory, First Hospital of Lanzhou University, Lanzhou 730000.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Aug 28;46(8):889-893. doi: 10.11817/j.issn.1672-7347.2021.200351.
The prevalence of abnormal glucose and lipid metabolism and its relevant diseases has increased year by year, and it has become a problem that threatens human health. Therefore, finding a more effective way to prevent and treat diseases related to abnormal glucose and lipid metabolism has become an urgent public problem. Agmatine is a polyamine substance which widely presents in mammals.It is a metabolite produced by decarboxylation of -arginine under the action of arginine decarboxylase, hence also known as decarboxylated arginine. Its biological effects have been confirmed. Previous studies have shown that agmatine possesses anti-diabetic effects in diabetic animals. Agmatine not only increases the insulin secretion form β-pancreatic cells to inhibit the hyperglycemia, but also attenuates insulin resistance in rats. Agmatine also plays a positive role in lipid metabolism disorders and related diseases by modulating lipid metabolism and fatty acid oxidation.
异常葡萄糖和脂质代谢及其相关疾病的患病率逐年增加，已成为威胁人类健康的问题。因此，寻找更有效的方法来预防和治疗与异常葡萄糖和脂质代谢相关的疾病已成为一个紧迫的公共问题。胍丁胺是一种广泛存在于哺乳动物中的多胺物质。它是精氨酸在精氨酸脱羧酶作用下脱羧产生的代谢物，因此也被称为脱羧精氨酸。其生物学作用已得到证实。先前的研究表明，胍丁胺在糖尿病动物中具有抗糖尿病作用。胍丁胺不仅通过增加β-胰岛细胞的胰岛素分泌来抑制高血糖，还可以减轻大鼠的胰岛素抵抗。胍丁胺还通过调节脂质代谢和脂肪酸氧化在脂质代谢紊乱及相关疾病中发挥积极作用。
