Liao George P, Abdelraheem Eman M M, Neochoritis Constantinos G, Kurpiewska Katarzyna, Kalinowska-Tłuścik Justyna, McGowan David C, Dömling Alexander
Department of Drug Design, University of Groningen , A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Janssen Infectious Diseases BVBA, Turnhoutseweg 30, 2340 Beerse, Belgium.
Org Lett. 2015 Oct 16;17(20):4980-3. doi: 10.1021/acs.orglett.5b02419. Epub 2015 Oct 6.
The direct macrocycle synthesis of α-isocyano-ω-carboxylic acids via an Ugi multicomponent reaction is introduced. This multicomponent reaction (MCR) protocol differs by being especially short, convergent, and versatile, giving access to 12-22 membered rings.
介绍了通过乌吉多组分反应直接大环合成α-异氰基-ω-羧酸的方法。这种多组分反应（MCR）方案的不同之处在于特别简短、收敛且通用，可用于合成12至22元环。
