如开放流动微灌注所示，司库奇尤单抗可分布至银屑病患者的真皮间质液中。 - Suppr

Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated by open flow microperfusion.

作者信息

Dragatin Christian, Polus Florine, Bodenlenz Manfred, Calonder Claudio, Aigner Birgit, Tiffner Katrin Irene, Mader Julia Katharina, Ratzer Maria, Woessner Ralph, Pieber Thomas Rudolf, Cheng Yi, Loesche Christian, Sinner Frank, Bruin Gerard

机构信息

Health - Institute for Biomedicine and Health Sciences, Joanneum Research Forschungsgesellschaft m.b.H., Graz, Austria.

Novartis Institutes for BioMedical Research, Basel, Switzerland.

出版信息

Exp Dermatol. 2016 Feb;25(2):157-9. doi: 10.1111/exd.12863. Epub 2015 Nov 23.

DOI:10.1111/exd.12863

PMID:26439798

Abstract

摘要

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Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated by open flow microperfusion.如开放流动微灌注所示，司库奇尤单抗可分布至银屑病患者的真皮间质液中。

Exp Dermatol. 2016 Feb;25(2):157-9. doi: 10.1111/exd.12863. Epub 2015 Nov 23.

Secukinumab in plaque psoriasis--results of two phase 3 trials.司库奇尤单抗治疗斑块状银屑病的两项 3 期临床试验结果。

N Engl J Med. 2014 Jul 24;371(4):326-38. doi: 10.1056/NEJMoa1314258. Epub 2014 Jul 9.

Population Pharmacokinetic Modeling of Secukinumab in Patients With Moderate to Severe Psoriasis.司库奇尤单抗在中度至重度银屑病患者中的群体药代动力学建模

J Clin Pharmacol. 2017 Jul;57(7):876-885. doi: 10.1002/jcph.876. Epub 2017 Mar 8.

Secukinumab (AIN457) for the treatment of psoriasis.司库奇尤单抗（AIN457）用于治疗银屑病。

Expert Rev Clin Immunol. 2015;11(11):1177-88. doi: 10.1586/1744666X.2015.1095092. Epub 2015 Oct 1.

Efficacy, safety and usability of secukinumab administration by autoinjector/pen in psoriasis: a randomized, controlled trial (JUNCTURE).司库奇尤单抗注射液/笔治疗银屑病的疗效、安全性和实用性：一项随机对照试验（JUNCTURE）。

J Eur Acad Dermatol Venereol. 2015 Jun;29(6):1082-90. doi: 10.1111/jdv.12751. Epub 2014 Sep 22.

Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate to severe plaque psoriasis: CLEAR, a randomized controlled trial.司库奇尤单抗在清除中重度斑块状银屑病患者皮肤方面优于乌司奴单抗：CLEAR，一项随机对照试验。

J Am Acad Dermatol. 2015 Sep;73(3):400-9. doi: 10.1016/j.jaad.2015.05.013. Epub 2015 Jun 17.

Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study.司库奇尤单抗治疗中重度斑块状银屑病的疗效和安全性：一项随机、双盲、安慰剂对照的 II 期剂量范围研究。

Br J Dermatol. 2013 Feb;168(2):412-21. doi: 10.1111/bjd.12110. Epub 2013 Jan 18.

Secukinumab administration by pre-filled syringe: efficacy, safety and usability results from a randomized controlled trial in psoriasis (FEATURE).预充式注射器给药司库奇尤单抗治疗银屑病的疗效、安全性和使用结果：一项随机对照试验（FEATURE）。

Br J Dermatol. 2015 Feb;172(2):484-93. doi: 10.1111/bjd.13348. Epub 2014 Dec 11.

Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study.司库奇尤单抗诱导和维持治疗中重度斑块状银屑病：一项随机、双盲、安慰剂对照、Ⅱ期方案探索研究。

Br J Dermatol. 2013 Feb;168(2):402-11. doi: 10.1111/bjd.12112.

Efficacy and safety of intravenous secukinumab in noninfectious uveitis requiring steroid-sparing immunosuppressive therapy.静脉注射司库奇尤单抗治疗需要激素免疫抑制治疗的非感染性葡萄膜炎的疗效和安全性。

Ophthalmology. 2015 May;122(5):939-48. doi: 10.1016/j.ophtha.2014.12.033. Epub 2015 Jan 29.

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Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated by open flow microperfusion.

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