Drobniak Artur, Kanecki Krzysztof, Grymowicz Monika, Radowicki Stanislaw
a Department of Gynecological Endocrinology and.
b Department of Health Care , Medical University of Warsaw , Warsaw , Poland.
Gynecol Endocrinol. 2016;32(2):128-31. doi: 10.3109/09513590.2015.1092512. Epub 2015 Oct 6.
Autoimmune thyroid disease (AITD) with elevated anti-thyroid peroxidase antibody (aTPO) levels appears in 12-25% of all women, apart from thyroid dysfunction. High titers of aTPO are more common in women with polycystic ovary syndrome and endometriosis. Elevated aTPO has been associated with infertility and poorer quality of life among euthyroid women, and may be related to other factors.
The aim of the study was to measure differences in serum leptin concentration between AITD+ and AITD- patients. Setting, patients and main outcome measures: The sample was comprised of 74 women who were hospitalized in the Department of Gynecological Endocrinology, Medical University of Warsaw. Data collected included age, body mass index (BMI), and serum aTPO, serum thyroid stimulating hormone (TSH), serum fT4, serum follitropin (FSH), serum estradiol and serum leptin. AITD positive status was defined as serum aTPO greater than 5.6 mIU/ml.
Serum leptin concentrations were significantly higher in AITD+ patients compared to AITD- patients (17.13 ng/ml [SD 7.66] versus 12.78 ng/ml [SD 7.28]; p < 0.05). No differences by AITD status were found in age, BMI, TSH, FSH, estradiol and fT4.
Serum leptin concentrations were higher in patients with AITD than in patients without AITD.
除甲状腺功能障碍外，抗甲状腺过氧化物酶抗体（aTPO）水平升高的自身免疫性甲状腺疾病（AITD）在所有女性中占比12% - 25%。高滴度的aTPO在多囊卵巢综合征和子宫内膜异位症女性中更为常见。aTPO升高与甲状腺功能正常女性的不孕及生活质量较差有关，且可能与其他因素相关。
本研究旨在测量AITD阳性和阴性患者血清瘦素浓度的差异。研究地点、患者及主要观察指标：样本包括74名在华沙医科大学妇科内分泌科住院的女性。收集的数据包括年龄、体重指数（BMI）、血清aTPO、血清促甲状腺激素（TSH）、血清游离甲状腺素（fT4）、血清促卵泡激素（FSH）、血清雌二醇和血清瘦素。AITD阳性状态定义为血清aTPO大于5.6 mIU/ml。
与AITD阴性患者相比，AITD阳性患者的血清瘦素浓度显著更高（17.13 ng/ml [标准差7.66] 对比12.78 ng/ml [标准差7.28]；p < 0.05）。在年龄、BMI、TSH、FSH、雌二醇和fT4方面，未发现AITD状态存在差异。
AITD患者的血清瘦素浓度高于非AITD患者。
