室温下通过二芳基甲烷与氟代芳烃的芳基化反应，由LDA介导合成三芳基甲烷
LDA-Mediated Synthesis of Triarylmethanes by Arylation of Diarylmethanes with Fluoroarenes at Room Temperature.
作者信息
Ji Xinfei, Huang Tao, Wu Wei, Liang Fang, Cao Song
机构信息
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology (ECUST) , Shanghai 200237, China.
出版信息
Org Lett. 2015 Oct 16;17(20):5096-9. doi: 10.1021/acs.orglett.5b02602. Epub 2015 Oct 6.
PMID:26440480
Abstract
A practical and convenient approach for the secondary C(sp(3))-H arylation of diarylmethanes with various fluoroarenes is described. The reaction proceeds smoothly in the presence of LDA (lithium diisopropylamide) at room temperature and affords triarylmethanes in moderate to high yields.
摘要
本文描述了一种实用且便捷的方法，用于实现二芳基甲烷与各种氟代芳烃的二级C(sp(3))-H芳基化反应。该反应在LDA（二异丙基氨基锂）存在下于室温下顺利进行，可中等至高产率地得到三芳基甲烷。
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