Mineev Konstantin S, Panova Stanislava V, Bocharova Olga V, Bocharov Eduard V, Arseniev Alexander S
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences RAS , str. Miklukho-Maklaya 16/10, Moscow, 117997 Russian Federation.
Biochemistry. 2015 Oct 20;54(41):6295-8. doi: 10.1021/acs.biochem.5b00851. Epub 2015 Oct 7.
The epidermal growth factor receptor (EGFR) is one of the most extensively studied receptor tyrosine kinases, as it is involved in a wide range of cellular processes and severe diseases. Recent works reveal that the single-helix transmembrane domains and cytoplasmic juxtamembrane regions play an important role in the receptor activation process. Here we present the results of our investigation of the spatial structure and mobility of the EGFR transmembrane domain and juxtamembrane regions in various membranelike environments, which shed light on the effects of the membrane physical properties and composition on the behavior of the juxtamembrane domain.
表皮生长因子受体（EGFR）是研究最为广泛的受体酪氨酸激酶之一，因为它参与了广泛的细胞过程和严重疾病。最近的研究表明，单螺旋跨膜结构域和胞质近膜区域在受体激活过程中发挥着重要作用。在此，我们展示了我们对EGFR跨膜结构域和近膜区域在各种类膜环境中的空间结构和流动性的研究结果，这些结果揭示了膜的物理性质和组成对近膜结构域行为的影响。
